Vertical and horizontal corneal epithelial thickness profiles determined by ultrahigh resolution optical coherence tomography.
Vertical and horizontal corneal epithelial thickness profiles determined by ultrahigh resolution optical coherence tomography.
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DOI：
10.1097/ico.0b013e31823f8d56
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发表时间：
2012-09
期刊：
影响因子：
2.8
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Du C;Wang J;Cui L;Shen M;Yuan Y
测量中央和外周角膜上皮的垂直和水平厚度轮廓，并确定白天是否发生变化。采用超高分辨率光谱域光学相干断层扫描技术，对20例正常人40只眼的角膜上皮厚度进行了测量。在上午10：00进行测量，并在6、8小时后再次进行测量。在上级区域的Bowman层边缘，基线垂直上皮厚度最薄，为42.9±4.1 μm。向角膜中央增厚（p<0.01）。中央上皮平均为52.5±2.4 μm，下中央周围区最厚，为55.2±2.5 μm。其向下边缘变薄，在Bowman层边缘达到51.3±5.1 μm（p<0.01）。沿着水平经线，鼻侧和颞侧Bowman层边缘上皮最厚，分别为58.6±5.1 μm和59.3±6.6 μm。它向中央角膜变薄。在8小时内，任何位置的上皮厚度均无显著变化。上皮厚度变化的水平和垂直子午线，并出现在白天稳定。
To measure vertical and horizontal thickness profiles of the central and peripheral corneal epithelium and determine if daytime changes occur. Forty eyes of 20 normal subjects were imaged by ultra-high resolution spectral domain optical coherence tomography to profile the corneal epithelial thickness from the edge of Bowman’s layer to the central cornea across the vertical and horizontal meridians. Measurements were made at 10:00 AM and again at 6, 8 hours later. The baseline vertical meridional epithelial thickness was thinnest, 42.9±4.1 μm, at the edge of Bowman’s layer in the superior region. It increased in thickness (p<0.01), towards the central cornea. The central epithelium averaged 52.5±2.4 μm, becoming thickest, 55.2±2.5 μm, in the inferior pericentral region. It thinned towards the inferior periphery, reaching 51.3±5.1 μm at the edge of Bowman’s layer (p<0.01). Along the horizontal meridian, the epithelium was thickest at the nasal side, 58.6±5.1 μm, and temporal side, 59.3±6.6 μm, near the edges of Bowman’s layer. It thinned towards the central cornea. There were no significant changes in the epithelial thickness at any location over 8 hours. Epithelial thickness varied over the horizontal and vertical meridians and appeared stable during the daytime.