Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction.
Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction.
复制标题
DOI：
10.1007/978-3-0348-9070-0_10
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jeffrey S. Rubin;Donald P. Bottaro;Marcio Chedid;Toru Miki;Dina Ron;G. R. Cunha;Paul W. Finch
中科院分区：
文献类型：
--
作者：
Jeffrey S. Rubin;Donald P. Bottaro;Marcio Chedid;Toru Miki;Dina Ron;G. R. Cunha;Paul W. Finch
Keratinocyte growth factor (KGF) is a member of the heparin-binding fibroblast growth factor family (FGF-7) with a distinctive pattern of target-cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, though from a variety of tissues. In contrast, KGF was produced solely by cells of mesenchymal origin, leading to the hypothesis that it might function as a paracrine mediator of mesenchymal-epithelial communication. Biochemical analysis and molecular cloning established that the KGF receptor (KGFR) was a tyrosine kinase isoform encoded by thefgfr-2gene. Many detailed investigations of KGF and KGFR expression in whole tissue and cell lines largely substantiated the pattern initially perceivedin vitroof mesenchymal and epithelial distribution, respectively. Moreover, functional assays in organ culture andin vivoand analysis of agents regulating KGF expression reinforced the idea that KGF acts predominantly on epithelial cells. While the data do not implicate a KGF autocrine loop in neoplasia, paracrine sources of factor or ligand-independent signaling by the KGFR might contribute to malignancy. Alternatively, because of its differentiation-promoting effects, KGF may retard processes that culminate in uncontrolled cell growth.
