Susceptibility induced MR line broadening: applications to brain iron mapping.
Susceptibility induced MR line broadening: applications to brain iron mapping.
复制标题
磁化率诱导的 MR 谱线展宽：在脑铁图谱中的应用。
DOI：
10.1097/00004728-198803000-00014
复制
发表时间：
1988
影响因子：
1.3
通讯作者：
Davis,KR
中科院分区：
文献类型：
--
作者：
Wismer,GL;Buxton,RB;Rosen,BR;Fisel,CR;Oot,RF;Brady,TJ;Davis,KR
由于神经组织中铁的存在而引起的磁化率变化可导致局部共振频率的偏移、由通过局部场梯度的水扩散引起的T2降低以及由于体素内的场不均匀性而引起的线加宽。在这项研究中，修改后的自旋回波相衬脉冲序列被用来映射在幻影和在体内的质子共振线宽。在含有不同浓度的Fe3 O4（磁铁矿）的琼脂凝胶中，谱线增宽机制允许通过测量局部共振谱线宽度来精确定位铁沉积物。此外，从数据中估计的线宽与铁浓度密切相关，表明该方法的潜在定量应用。该技术已应用于亚急性脑梗塞的铁标测。这些数据表明，共振线宽可能是一个有用的措施，脑铁含量。
Magnetic susceptibility variations due to the presence of iron in neural tissue can result in a shift of local resonance frequency, decreased T2 resulting from water diffusion through local field gradients, and line broadening due to field inhomogeneity within a voxel. In this study, modified spin echo phase contrast pulse sequences were used to map proton resonance line widths in phantoms and in vivo. In agar gels containing varying concentrations of Fe 3 O 4 (magnetite), line broadening mechanisms permitted accurate spatial localization of iron deposits from measurement of local resonance line widths. Furthermore, line widths estimated from the data were strongly correlated with iron concentrations, indicating the potential quantitative applications of the method. The technique was applied clinically to map iron in subacute brain hemorrhages. These data suggest that resonance line widths may be a useful measure of brain iron content.