Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
复制标题
Kappa 阿片受体刺激大鼠大脑中的磷酸肌醇周转。
DOI：
10.1016/0024-3205(90)90323-j
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发表时间：
1990
期刊：
影响因子：
6.1
通讯作者：
Hoss,W
中科院分区：
文献类型：
--
作者：
Periyasamy,S;Hoss,W
The effects of various subtype-selective opioid agonists and antagonist on the phosphoinositide (Pl) turnover response were investigated in the rat brain. The κ-agonists U-50,488H and ketocyclazocine produced a concentration-dependent increase in the accumulation of IP's in hippocampal slices. The other κ-agonists Dynorphin-A (1-1-13) amide, and its protected analog D[Ala]2-dynorphin-A (1–13) amide also produced a significant increase in the formation of [3H]-lP's, whereas the μ-selective agonists [D-Ala2-N-Me-Phe4-Gly5-ol]-enkephalin and morphine and the δ-selective agonist [D-Pen2,5]-enkephalin were ineffective. The increase in lP's formation elicited by U-50,488H was partially antagonized by naloxone and more completely antagonized by the κ-selective antagonists nor-binaltorphimine and MR 2266. The formation of lP's induced by U-50,488H varies with the regions of the brain used, being highest in hippocampus and amygdala, and lowest in striatum and pons-medulla. The results indicate that brain κ- but neither μ- nor δ-receptors are coupled to the Pl turnover response.
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影响因子：
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作者：
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DOI：
--
发表时间：
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DOI：
10.1042/bj2380537
发表时间：
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期刊：
The Biochemical journal
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
VOGEL, Z