Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell carcinoma.
Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell carcinoma.
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晚期生殖细胞癌初次化疗后血清人绒毛膜促性腺激素水平下降的预后意义。
DOI：
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发表时间：
1984
影响因子：
39.2
通讯作者：
F. Torti
中科院分区：
文献类型：
--
作者：
V. Picozzi;F. Freiha;J. Hannigan;F. Torti
我们连续研究了40例晚期生殖细胞癌患者，这些患者的血清绒毛膜促性腺激素(HCG)水平升高，以评估化疗后HCG水平下降幅度的预后价值。如果在第一个化疗周期后血清HCG水平未能恢复正常，如果第22天HCG水平/第1天水平大于1/200(0.005)，则预测化疗不完全反应的敏感性为90%，预测值为94%。相反，如果第22天的水平在正常范围内，或者如果第22天的水平/第1天的水平低于1/200，则可以预测对化疗的成功反应(定义为停止化疗后的一年无病间隔)，敏感性为95%，一个化疗周期后的预测值为91%。总体而言，40名患者中有37名患者的长期化疗反应被正确预测(与使用卡方检验的实际患者结果相比，p<0.0001)。
We studied 40 consecutive patients with advanced germ-cell carcinoma and elevated serum levels of human chorionic gonadotropin (HCG) to assess the prognostic value of the magnitude of the decline in HCG levels after chemotherapy. If serum levels failed to become normal after the first chemotherapy cycle and if the day-22 HCG level/day-1 level was greater than 1/200 (0.005), an incomplete response to chemotherapy could be predicted with a sensitivity of 90% and a predictive value of 94%. Conversely, if the day-22 level was within normal limits, or if the day-22 level/day-1 level was less than 1/200, a successful response to chemotherapy (defined as a 1-year disease-free interval following cessation of chemotherapy) could be predicted with a sensitivity of 95% and a predictive value of 91% after one chemotherapy cycle. Overall, the long-term response to chemotherapy was correctly predicted in 37 of 40 patients (p less than 0.0001, compared with actual patient outcome using the chi-squared test).
睾丸癌作为可治愈肿瘤的模型：理查德和辛达·罗森塔尔基金会奖讲座。
影响因子：
11.2
作者：
Einhorn,LH
通讯作者：
Einhorn,LH
影响因子：
11.2
作者：
G. Bosl;N. Geller;C. Cirrincione;N. Vogelzang;B. Kennedy;W. Whitmore;D. Vugrin;H. Scher;J. Nisselbaum;Robert B. Golbery
通讯作者：
G. Bosl;N. Geller;C. Cirrincione;N. Vogelzang;B. Kennedy;W. Whitmore;D. Vugrin;H. Scher;J. Nisselbaum;Robert B. Golbery
睾丸转移性生殖细胞肿瘤患者的血清肿瘤标志物。
DOI：
10.1016/0002-9343(83)91164-6
发表时间：
1983
期刊：
The American journal of medicine
影响因子：
--
作者：
Bosl,GJ;Geller,NL;Cirrincione,C;Nisselbaum,J;Vugrin,D;WhitmoreJr,WF;Golbey,RB
通讯作者：
Golbey,RB