Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice.
Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice.
复制标题
膳食中富含 EPA 的鱼油对尼古丁小鼠主动脉壁弹性蛋白纤维降解的抑制作用。
作者：
Hirona Kugo;N. Zaima;M. Onozato;Chie Miyamoto;Keisuke Hashimoto;Kenichi Yanagimoto;T. Moriyama
腹主动脉瘤（AAA）是一种涉及腹主动脉逐渐扩张的血管疾病。最近的研究表明，尼古丁是香烟烟雾中的主要成分，与AAA的发展和破裂密切相关。尼古丁通过增加氧化应激和基质金属蛋白酶（MMP）-2表达削弱血管壁来加速AAA的发展。然而，关于预防尼古丁诱导的AAA知之甚少。在AAA发作之前，通过功能性食物因素预防血管壁弱化的非手术方法将是手术的有价值的选择。鱼油是一种功能性食品，富含具有抗炎作用的n-3多不饱和脂肪酸。在这项研究中，我们评估了膳食鱼油对小鼠模型中尼古丁给药引起的主动脉壁弱化的影响。组织学分析表明，膳食鱼油抑制尼古丁给药小鼠的弹性蛋白纤维降解。此外，膳食鱼油还抑制了MMP-12的蛋白水平、巨噬细胞浸润和血管壁的氧化应激。这些结果表明，鱼油可以通过抑制尼古丁引起的弹性蛋白纤维降解来抑制血管壁的弱化。通过抑制尼古丁诱导的血管壁弱化，鱼油可能有助于防止AAA的发展。
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta. Recent studies suggest that nicotine, which is a primary component in cigarette smoke, is closely associated with the development and rupture of an AAA. Nicotine accelerates AAA development through the weakening of the vascular wall by increasing oxidative stress and matrix metalloproteinase (MMP)-2 expression. However, little is known about preventing the AAA induced by nicotine. A non-surgical means of preventing the weakening of the vascular wall before the onset of AAA by functional food factors would be a valuable option over surgery. Fish oil is a functional food that is rich in n-3 polyunsaturated fatty acids that have an anti-inflammatory effect. In this study, we evaluated the effect of dietary fish oil on the weakening of the aortic wall due to nicotine administration in a mouse model. Histological analysis showed that the dietary fish oil suppressed the degradation of elastin fibers in the nicotine-administered mice. Additionally, the dietary fish oil suppressed the protein level of MMP-12, macrophage infiltration, and the oxidative stress in the vascular wall. These results suggest that fish oil could suppress the weakening of the vascular wall by suppressing the elastin fiber degradation caused by nicotine. By suppressing the nicotine induced weakening of the vascular wall, fish oil might help prevent the development of AAA.
DOI：
10.1056/nejmcibr0905244
发表时间：
2009-09-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Weintraub NL
通讯作者：
Weintraub NL
影响因子：
15.9
作者：
Curci, JA;Liao, SX;Thompson, RW
通讯作者：
Thompson, RW