Cancer Immunotherapy Using CAR-T Cells: From the Research Bench to the Assembly Line.
Cancer Immunotherapy Using CAR-T Cells: From the Research Bench to the Assembly Line.
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DOI：
10.1002/biot.201700097
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发表时间：
2018-03
影响因子：
4.7
通讯作者：
Ramos CA
中科院分区：
文献类型：
--
作者：
Gomes-Silva D;Ramos CA
癌症治疗的重点最近已转向靶向治疗，包括免疫治疗，这允许更好的个性化护理，并希望增加患者的成功概率。具体而言，经遗传修饰以表达嵌合抗原受体（汽车; CAR-T细胞）的T细胞已经产生了令人兴奋的结果。最近这种尖端疗法的临床成功有助于推动CAR-T细胞获得更广泛的应用。然而，在广泛使用CAR-T细胞作为标准治疗之前，需要解决几个限制。在这里，我们将简要介绍过继性T细胞治疗的背景，然后简要概述汽车的结构，它们如何被引入T细胞，以及如何在体外实现CAR-T细胞扩增和选择。我们将讨论CAR设计中的一些挑战，以及大规模CAR-T细胞制造中出现的困难，这些困难需要解决才能实现这种细胞疗法的成功商业化。最后，我们将讨论已经出现的事态发展。
The focus of cancer treatment has recently shifted towards targeted therapies, including immunotherapy, which allow better individualization of care and are hoped to increase the probability of success for patients. Specifically, T cells genetically modified to express chimeric antigen receptors (CARs; CAR-T cells) have generated exciting results. Recent clinical successes with this cutting-edge therapy have helped to push CAR-T cells towards approval for wider use. However, several limitations need to be addressed before the widespread use of CAR-T cells as a standard treatment. Here, we will give a succinct background on adoptive T-cell therapy, followed by a brief overview of the structure of CARs, how they are introduced into T cells, and how CAR-T cell expansion and selection is achieved in vitro. We will discuss some of the challenges in CAR design, as well as the difficulties that arise in large-scale CAR-T cell manufacture that will need to be addressed to achieve successful commercialization of this type of cell therapy. Finally, we will discuss developments already on the horizon.
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影响因子：
10.1
作者：
Hudecek M;Sommermeyer D;Kosasih PL;Silva-Benedict A;Liu L;Rader C;Jensen MC;Riddell SR
通讯作者：
Riddell SR
影响因子：
12.8
作者：
Cartellieri M;Feldmann A;Koristka S;Arndt C;Loff S;Ehninger A;von Bonin M;Bejestani EP;Ehninger G;Bachmann MP
通讯作者：
Bachmann MP
影响因子：
82.9
作者：
Long, Adrienne H.;Haso, Waleed M.;Shern, Jack F.;Wanhainen, Kelsey M.;Murgai, Meera;Ingaramo, Maria;Smith, Jillian P.;Walker, Alec J.;Kohler, M. Eric;Venkateshwara, Vikas R.;Kaplan, Rosandra N.;Patterson, George H.;Fry, Terry J.;Orentas, Rimas J.;Mackall, Crystal L.
通讯作者：
Mackall, Crystal L.
影响因子：
64.8
作者：
Eyquem J;Mansilla-Soto J;Giavridis T;van der Stegen SJ;Hamieh M;Cunanan KM;Odak A;Gönen M;Sadelain M
通讯作者：
Sadelain M
影响因子：
45.3
作者：
Ahmed, Nabil;Brawley, Vita S.;Gottschalk, Stephen
通讯作者：
Gottschalk, Stephen