Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
复制标题
DOI：
10.1042/bst0301091
复制
发表时间：
2002-11-01
影响因子：
3.9
通讯作者：
Horton, JD
中科院分区：
文献类型：
--
作者：
Horton, JD
固醇调节元件结合蛋白（SREBPs）是一类调节脂质稳态的转录因子。三种SREBP亚型控制胆固醇、脂肪酸、三酰甘油和磷脂生物合成所需的30多种基因的表达。每种SREBP亚型的独特调节和活化特性促进细胞膜以及肝细胞中极低密度脂蛋白形成所需的所有必需脂质构建块的协调调节。
Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.