TRPV4 plays an evolutionary transduction of osmotic and conserved role in the mechanical stimuli in live animals
TRPV4 plays an evolutionary transduction of osmotic and conserved role in the mechanical stimuli in live animals
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DOI：
10.1113/jphysiol.2005.088963
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发表时间：
2005-08-15
影响因子：
5.5
通讯作者：
Liedtke, W
中科院分区：
文献类型：
--
作者：
Liedtke, W
TRPV 4离子通道，以前称为香草酸受体相关的血管激活通道（VR-OAC），在体内的渗透和机械刺激的转导中发挥作用。在trpv 4基因敲除的小鼠中，发现TRPV 4对于维持全身渗透压平衡和响应有害机械刺激的正常阈值是必需的。在秀丽隐杆线虫TRPV突变体转基因哺乳动物TRPV 4，哺乳动物转基因指导渗透和机械回避反应的背景下，ASH的伤害性神经元。在这一点上，TRPV 4在体内门控的分子机制尚不清楚，必须确定。
The TRPV4 ion channel, previously named vanilloid receptor-related osmotically activated channel (VR-OAC), functions in vivo in the transduction of osmotic and mechanical stimuli. In trpv4 null mice, TRPV4 was found to be necessary for the maintenance of systemic osmotic equilibrium, and for normal thresholds in response to noxious mechanical stimuli. In a Caenorhabditis elegans TRPV mutant transgenic for mammalian TRPV4, the mammalian transgene was directing the osmotic and mechanical avoidance response in the context of the ASH 'nociceptive' neurone. Molecular mechanisms of gating of TRPV4 in vivo are not known at this point and have to be determined.