Secretion of salt and water into the medullary collecting duct of Ringer-infused rats.
Secretion of salt and water into the medullary collecting duct of Ringer-infused rats.
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盐和水分泌到林格输注大鼠的髓质集合管中。
DOI：
10.1152/ajplegacy.1975.228.2.565
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Sonnenberg
中科院分区：
文献类型：
--
作者：
H. Sonnenberg
采用微导管技术，在麻醉大鼠中研究了集合管对细胞外液容量扩张的肾反应的贡献。在静脉输注林格氏液（0.25 ml/min/100 g体重）期间，液体、钠和钾的尿排泄量分别为365穆尔/min/g肾脏重量（V）、52.6 μ eq/min/g肾脏重量（UNaV）和3.86 μ eq/min/g肾脏重量（UKV），分别占过滤负荷的23%、24%和65%。从皮质和外髓质收集管液的分析表明，在这些肾单位段离子和水的持续净重吸收，相反，在内髓质净分泌钠，钾，和液体进入收集管被证明。加入的钠和水相当于约10%的过滤负荷。它的结论是，在极端的静脉液体负荷的压力下，肾小管分泌的盐和水进入内髓集合管有助于重要的利尿和尿钠排泄。这种分泌的机制仍然没有确定。
Using a microcatheterization technique, the contribution of the collecting duct to the renal response to extracellular fluid volume expansion was studied in anesthetized rats. During intravenous infusion of Ringer solution (0.25 ml/min per 100 g body wt), urinary excretion of fluid, sodium, and potassium was 365 mul/min per g kidney wt (V), 52.6 mueq/min per g kidney wt (UNaV), and 3.86 mueq/min per g kidney wt (UKV), representing 23, 24, and 65% of filtered load, respectively. Analysis of collecting duct fluid from cortex and outer medulla indicated continued net reabsorption of ions and water in these nephron segments; in contrast, in inner medulla net secretion of Na, K, and fluid into the collecting duct was demonstrated. Addition of sodium and water was equivalent to approximately 10% of filtered load. It is concluded that under the stress of extreme intravenous fluid loading tubular secretion of salt and water into the inner medullary collecting duct contributes importantly to diuresis and natriuresis. The mechanism of such secretion remains undetermined.