Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine
Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine
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DOI：
10.1007/s13181-016-0588-y
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Boyer, Edward W.
中科院分区：
文献类型：
--
作者：
Lydecker, Alicia G.;Sharma, Abhisheak;Boyer, Edward W.
介绍Kratom（Mitragyna speciosa），一种原产于东南亚的植物，已经使用了几个世纪，其兴奋剂和鸦片样作用。Mitragynine和7-hydroxymitragynine是M. speciosa，是生物碱主要负责Kratom的生物和精神活性的配置文件，并可能有助于其有问题的使用.我们购买了几个市售Kratom类似物进行分析，并通过我们的结果，目前的证据可能掺杂的高度有效和上瘾的植物生物碱，方法采用高效液相色谱-串联质谱法（LC-MS/MS）同时测定了7-羟基米曲宁和米曲宁的含量。在市售Kratom补充剂的甲醇提取物中的羟基mitragynine.结果我们发现多个商业Kratom产品具有浓度7-羟基mitragynine，基本上高于那些发现在原料M。结论我们已经发现多个包装的商业Kratom产品可能含有人工升高浓度的7-羟基mitragynine，负责M.关于其机制和副作用。这项研究描述了一种独特的产品掺假形式，强调了增加对含Kratom补充剂的膳食补充剂监督的重要性。
Introduction Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has been used for centuries for its stimulant and opium-like effects. Mitragynine and 7-hydroxymitragynine, exclusive to M. speciosa, are the alkaloids primary responsible for Kratom's biologic and psychoactive profile, and likely contribute to its problematic use. We purchased several commercially available Kratom analogs for analysis and through our results, present evidence of probable adulteration with the highly potent and addictive plant alkaloid, 7-hydroxymitragynine.Methods A simple and sensitive LC-MS/MS method was developed for simultaneous quantification of mitragynine and 7-hydroxymitragynine in methanol extract of marketed Kratom supplements.Results We found multiple commercial Kratom products to have concentrations of 7-hydroxymitragynine that are substantially higher than those found in raw M. speciosa leaves.Conclusions We have found multiple packaged commercial Kratom products likely to contain artificially elevated concentrations of 7-hydroxymitragynine, the alkaloid responsible for M. speciosa's concerning mechanistic and side effect profile. This study describes a unique form of product adulteration, which stresses the importance of increased dietary supplement oversight of Kratom-containing supplements.