Impact of isolated obesity on ICSI outcome
Impact of isolated obesity on ICSI outcome
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DOI：
10.1016/s1472-6483(10)60249-0
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发表时间：
2008-10-01
影响因子：
4
通讯作者：
Yarali, H.
中科院分区：
文献类型：
--
作者：
Esinler, I.;Bozdag, G.;Yarali, H.
本研究的目的是评估孤立性肥胖对胞浆内单精子注射（ICSI）结果的影响。775例接受1113个ICSI周期的患者根据体重指数（BMI）进行分类：I组(BMI 18.5-24.9 kg/m(2)；正常体重n = 627个周期)，第二组(BMI 25.0-29.9 kg/m m(2)；超重;n = 339个周期)和3组(BMI >= 30 kg/m(2)；肥胖;N = 147个周期)。1组63个（10.0%）疗程取消，2组53个（15.6%）疗程取消，3组26个（17.7%）疗程取消（1组与2、3组比较P < 0.05）。尽管2组和3组的促性腺激素总消耗量显著高于1组，但1组在人绒毛膜促性腺激素给药当日的平均血清雌二醇水平显著高于1组（P < 0.05）。3组的卵丘-卵母细胞复合体、中期卵母细胞和双原核卵母细胞数量显著低于1组（P < 0.05）。但三组受精率、平均移植胚胎数、平均1级胚胎数、临床妊娠、着床率、多胎率和流产率比较，差异均无统计学意义。2、3组冷冻胚胎周期率显著低于1组（P < 0.05）。
The aim of this study was to assess the impact of isolated obesity on the outcome of intracytoplasmic sperm injection (ICSI). A total of 775 patients undergoing 1113 ICSI cycles were categorized on the basis of body mass index (BMI): group I (BMI 18.5-24.9 kg/m(2); normal weights n = 627 cycles), group 2 (BMI 25.0-29.9 kg/m m(2); overweight; n = 339 cycles) and group 3 (BMI >= 30 kg/m(2); obese; n = 147 cycles). Sixty-three (10.0%) cycles in group 1, 53 (15.6%) cycles in group 2 and 26 cycles (17.7%) in group 3 were cancelled (P < 0.05 for group 1 versus groups 2 and 3). Despite the significantly higher total gonadotrophin consumption in groups 2 and 3 compared with group 1, the mean serum oestradiol level on the day of human chorionic gonadotrophin administration was significantly higher in group 1 (P < 0.05). The number of cumulus-oocyte complexes, metaphase II oocytes, and two-pronucleated oocytes were significantly lower in group 3 compared with group 1 (P < 0.05). However, fertilization rate, the mean number of embryos transferred, the mean number of grade 1 embryos transferred, clinical pregnancy, implantation, multiple pregnancy and miscarriage rates were comparable among the three groups. The rate of cycles with cryopreservable embryos was significantly lower in groups 2 and 3 compared with group 1 (P < 0.05).