Enhanced neuronal response induced by fast inhibition
Enhanced neuronal response induced by fast inhibition
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DOI：
10.1103/physreve.73.010903
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Rinzel, J
中科院分区：
文献类型：
--
作者：
Dodla, R;Rinzel, J
我们报告了抑制性突触输入的促进作用，它可以增强神经元的放电率，与传统的抑制抑制放电的观点相反。我们使用霍奇金-赫胥黎模型来研究这一现象，该模型具有阈下兴奋性和抑制性输入的随机泊松序列。增强发生时，偶然的，短暂的抑制导致兴奋与有利的时间和反直觉诱导减少尖峰阈值。并通过双变量模型的相平面分析说明了其基本机理。
We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.