Purinergic Regulation of Neutrophil Function.
Purinergic Regulation of Neutrophil Function.
复制标题
中性粒细胞功能的嘌呤能调节
DOI：
10.3389/fimmu.2018.00399
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Chen D
中科院分区：
文献类型：
--
作者：
Wang X;Chen D
嘌呤能信号是以核苷酸（特别是ATP）和腺苷为传递分子的信号，在免疫系统中起着重要的作用。在细胞外室中，ATP主要通过激活P2受体作为促炎分子发挥作用，而腺苷主要通过激活P1受体作为抗炎分子发挥作用。中性粒细胞是循环中最丰富的免疫细胞，并已成为炎症期间协调一系列复杂事件的重要组成部分。然而，由于嗜中性粒细胞衍生的炎性因子的破坏性性质，中性粒细胞活化是微调的，并且嘌呤能信号传导密切参与该过程。事实上，改变P2和P1信号之间的平衡对于中性粒细胞适当发挥其免疫活性至关重要。在这里，我们回顾了嘌呤能信号在调节中性粒细胞功能中的作用，并讨论了靶向嘌呤能信号治疗嗜中性粒细胞相关感染性和炎症性疾病的潜力。
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through activation of P2 receptors, whereas adenosine mostly functions as an anti-inflammatory molecule through activation of P1 receptors. Neutrophils are the most abundant immune cells in circulation and have emerged as an important component in orchestrating a complex series of events during inflammation. However, because of the destructive nature of neutrophil-derived inflammatory agents, neutrophil activation is fine-tuned, and purinergic signaling is intimately involved in this process. Indeed, shifting the balance between P2 and P1 signaling is critical for neutrophils to appropriately exert their immunologic activity. Here, we review the role of purinergic signaling in regulating neutrophil function, and discuss the potential of targeting purinergic signaling for the treatment of neutrophil-associated infectious and inflammatory diseases.