Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
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DOI：
10.1016/s0165-5728(03)00155-3
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发表时间：
2003-06-01
影响因子：
3.3
通讯作者：
Yamamura, T
中科院分区：
文献类型：
--
作者：
Koike, F;Satoh, J;Yamamura, T
干扰素β（IFNβ）治疗多发性硬化症（MS）的分子机制仍有待表征。利用 cDNA 微阵列技术，我们比较了 IFNbeta-1b 治疗前后复发缓解型多发性硬化症 T 细胞和非 T 细胞的基因表达谱。治疗后 3 个月和 6 个月，IFNβ 治疗显着改变了 1263 个基因中 21 个基因的表达。这些基因包括九个具有 IFN 响应启动子元件的基因。虽然 Th1 或 Th2 标记基因没有变化，但有些变化是出乎意料的，但与 IFNβ 对 MS 的有益作用相一致。 (C) 2003 Elsevier Science B.V. 保留所有权利。
The molecular mechanisms for the interferon beta (IFNbeta) treatment of multiple sclerosis (MS) remain to be characterized. Using cDNA microarray technology, we have compared the gene expression profile of T and non-T cells derived from relapsing-remitting MS before and after treatment with IFNbeta-1b. IFNbeta treatment significantly altered expression of 21 genes out of 1263 at 3 and 6 months after treatment. These genes included nine with IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some of the changes were unexpected but coincided with the beneficial effect of IFNbeta in MS. (C) 2003 Elsevier Science B.V. All rights reserved.