Copy number variations and expression of MPDZ are prognostic biomarkers for clear cell renal cell carcinoma.
Copy number variations and expression of MPDZ are prognostic biomarkers for clear cell renal cell carcinoma.
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MPDZ 的拷贝数变异和表达是透明细胞肾细胞癌的预后生物标志物。
DOI：
10.18632/oncotarget.20220
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发表时间：
2017-10-03
期刊：
影响因子：
--
通讯作者：
Liu JY
中科院分区：
文献类型：
--
作者：
Huang YS;Liu WB;Han F;Yang JT;Hao XL;Chen HQ;Jiang X;Yin L;Ao L;Cui ZH;Cao J;Liu JY
重要拷贝数变异（CNV）在肾透明细胞癌（ccRCC）中起着至关重要的作用。MPDZ抑制与渗透压反应和癌症相关的生物学过程相关的细胞极性。为了阐明MPDZ的CNV在ccRCC进展中的作用，我们分析了来自癌症基因组图谱数据门户的ccRCC患者中的CNV和MPDZ的表达以及预后。值得注意的是，我们发现MPDZ的缺失是常见的CNV，其存在于28.65%的ccRCC患者中。随着肿瘤的进展，MPDZ缺失率显著增加（I期19.38%，II期20.00%，III期40.94%，IV期45.00%）。MPDZ的缺失显著增加了ccRCC的风险（P=0.0025）。与其缺失相关的MPDZ低表达与ccRCC患者的不良结局显著相关（P=0.0342）。组织芯片免疫组化分析显示，MPDZ在肿瘤组织中的表达低于癌旁组织（P<0.01）。Kaplan-Meier生存曲线显示，MPDZ低表达的ccRCC患者的生存期显著短于MPDZ高表达的患者（P=0.002）。这些结果表明，与CNV相关的低MPDZ表达是ccRCC患者预后的潜在生物标志物。
The vital copy number variation (CNV) plays a crucial role in clear cell renal cell carcinoma (ccRCC). MPDZ inhibit cell polarity associate with osmotic pressure response and cancer-related biological processes. In order to clarify the role of the CNV of MPDZ in the progression of ccRCC, we analyzed the CNV and expression of MPDZ and prognosis in ccRCC patients from The Cancer Genome Atlas data portal. Notably, we found that the deletion of MPDZ was the common CNV, which was present in 28.65% of ccRCC patients. With the development of tumors, the percentage of MPDZ deletion increased significantly (19.38% in stage I; 20.00% in stage II; 40.94% in stage III; and 45.00% in stage IV). The deletion of MPDZ significantly increased ccRCC risk (P=0.0025). Low MPDZ expression associated with its deletion was significantly associated with adverse outcomes in ccRCC patients (P=0.0342). Furthermore, immunohistochemical analysis by tissue microarray showed that MPDZ was expressed at lower levels in tumor tissues compared with adjacent tissues (P<0.01). Kaplan–Meier survival curves showed that ccRCC patients with low MPDZ expression had significantly shorter survival than those with high MPDZ expression (P=0.002). These results indicated that low MPDZ expression associated with CNV is a potential biomarker for the prognosis of ccRCC patients.
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DOI：
10.1158/1078-0432.ccr-12-3886
发表时间：
2013-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Hakimi AA;Ostrovnaya I;Reva B;Schultz N;Chen YB;Gonen M;Liu H;Takeda S;Voss MH;Tickoo SK;Reuter VE;Russo P;Cheng EH;Sander C;Motzer RJ;Hsieh JJ;ccRCC Cancer Genome Atlas (KIRC TCGA) Research Network investigators
通讯作者：
ccRCC Cancer Genome Atlas (KIRC TCGA) Research Network investigators
影响因子：
11.5
作者：
Maroto, Pablo;Rini, Brian
通讯作者：
Rini, Brian
影响因子：
3.7
作者：
Assemat, Emeline;Crost, Emmanuelle;Massey-Harroche, Dominique
通讯作者：
Massey-Harroche, Dominique
影响因子：
5.2
作者：
Katoh M
通讯作者：
Katoh M
影响因子：
4.8
作者：
Coyne, CB;Voelker, T;Bergelson, JM
通讯作者：
Bergelson, JM