Regional grey matter changes in patients with migraine: a voxel-based morphometry study
Regional grey matter changes in patients with migraine: a voxel-based morphometry study
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DOI：
10.1111/j.1468-2982.2008.01550.x
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发表时间：
2008-06-01
期刊：
影响因子：
4.9
通讯作者：
Koh, S-B
中科院分区：
文献类型：
--
作者：
Kim, J. H.;Suh, S. -I;Koh, S-B
我们使用基于体素的形态测量 (VBM) 来比较 20 名偏头痛患者（5 名有先兆，15 名无先兆）与正常常规磁共振成像结果和 33 名年龄和性别匹配的健康对照之间的灰质体积 (GMV)。还进行了一项单独的分析，以描绘 GMV 变化与头痛持续时间或终生头痛频率之间可能的相关性。与对照组相比，偏头痛患者双侧岛叶、运动/前运动、前额叶、扣带皮层、右后顶叶皮层和眶额皮层的 GMV 显着降低（P < 0.001，体素水平多重比较未校正；小体积校正后校正 P < 0.05）。所有区域的 GMV 变化均与头痛持续时间和终生头痛频率呈负相关（P < 0.05，Pearson 相关性检验）。我们发现偏头痛患者灰质结构发生变化的证据。我们发现，随着头痛持续时间的增加和头痛频率的增加，GMV 逐渐减少，这表明随着时间的推移，偏头痛的反复发作会导致参与中枢疼痛处理的几个大脑区域发生选择性损伤。
We used voxel-based morphometry (VBM) to compare grey matter volume (GMV) between 20 migraine patients (five with aura and 15 without aura) with normal conventional magnetic resonance imaging findings and 33 healthy controls matched for age and sex. A separate analysis was also performed to delineate a possible correlation between the GMV changes and the headache duration or lifetime headache frequency. When compared with controls, migraine patients had significant GMV reductions in the bilateral insula, motor/premotor, prefrontal, cingulate cortex, right posterior parietal cortex, and orbitofrontal cortex (P < 0.001, uncorrected for multiple comparisons at a voxel level; corrected P < 0.05 after small volume corrections). All regions of the GMV changes were negatively correlated with headache duration and lifetime headache frequency (P < 0.05, Pearson's correlation test). We found evidence for structural grey matter changes in patients with migraine. Our findings of progressive GMV reductions in relation to increasing headache duration and increasing headache frequency suggest that repeated migraine attacks over time result in selective damage to several brain regions involved in central pain processing.