The expression of MHC antigens by human teratocarcinoma derived cell lines.
The expression of MHC antigens by human teratocarcinoma derived cell lines.
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人畸胎癌衍生细胞系 MHC 抗原的表达。
DOI：
10.1111/j.1399-0039.1981.tb00736.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Goodfellow,PN
中科院分区：
文献类型：
--
作者：
Andrews,PW;Bronson,DL;Wiles,MV;Goodfellow,PN
我们使用流式微荧光测定法定量研究源自人畸胎癌的细胞系的 HLA-A、B 和 C 抗原以及 β2 微球蛋白的表达。尽管所有检查的细胞系均表达低水平的这些细胞表面分子，但没有证据表明任何培养物中存在离散的 HLA-A、B、C/β2-微球蛋白阳性和阴性亚群。相反，使用类似的技术，没有发现鼠胚胎癌细胞系表达同源的H-2抗原。研究表明，人胚胎癌细胞与小鼠胚胎癌细胞的不同之处可能在于表达低水平的主要组织相容性抗原。
We have used flow microflourimetry to investigate quantitatively the expression of HLA‐A, B and C antigens, and β2microglobulin, by cell lines derived from human teratocarcinomas. Although low levels of these cell surface molecules were expressed by all the lines examined, there was no evidence of discrete HLA‐A, B, C/β2‐microglobulin positive and negative subpopulations in any cultures. In contrast, using similar techniques, no murine embryonal carcinoma cell line was found to express the homologous H‐2 antigens. It is suggested that human embryonal carcinoma cells may differ from their mouse counterparts by expressing low levels of major histocompatibility antigens.