Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease
Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease
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DOI：
10.1161/01.cir.93.6.1107
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发表时间：
1996-03-15
期刊：
影响因子：
37.8
通讯作者：
Vita, JA
中科院分区：
文献类型：
--
作者：
Levine, GN;Frei, B;Vita, JA
Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease.Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46+/-8 to 114+/-11 mu mol/L, P=.001). In the prospectively defined group of patients with an abnormal baseline response (
