PD-L1hi B cells are critical regulators of humoral immunity
PD-L1hi B cells are critical regulators of humoral immunity
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DOI：
10.1038/ncomms6997
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发表时间：
2015-01-01
影响因子：
16.6
通讯作者：
Fallon, Padraic G.
中科院分区：
文献类型：
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作者：
Khan, Adnan R.;Hams, Emily;Fallon, Padraic G.
特异性B细胞亚群可以调节T细胞免疫应答，并且被称为调节性B细胞（布雷格）。在小鼠和人中描述的大多数布雷格细胞已通过IL-10产生鉴定，并且已知其抑制过敏和自身免疫。然而，也会发生不依赖于IL-10的布雷格细胞介导的免疫抑制。我们发现布雷格细胞在调节由CD 4（+）CXCR 5（+）PD-1（+）滤泡辅助性T细胞介导的体液免疫中起关键作用，并且可以通过PD-L1的表达升高来抑制自身免疫性疾病中的炎症。我们还发现这些B细胞对α CD 20 B细胞耗竭具有抗性。这项工作描述了布雷格细胞是如何在体液稳态中发挥关键作用的，并可能对自身免疫性疾病的调节产生影响。
Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4(+)CXCR5(+)PD-1(+) follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to alpha CD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.