Paucity of genes on the Drosophila X chromosome showing male-biased expression
Paucity of genes on the Drosophila X chromosome showing male-biased expression
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DOI：
10.1126/science.1079190
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发表时间：
2003-01-31
期刊：
影响因子：
56.9
通讯作者：
Oliver, B
中科院分区：
文献类型：
--
作者：
Parisi, M;Nuttall, R;Oliver, B
在许多生物体中，性染色体是决定性别二型性的主要因素。这些染色体被认为是通过祖先常染色体对的分化而产生的，几乎可以肯定地说，它们受到配偶和雌性不同选择的影响。探索性染色体与常染色体的不同之处是非常容易进行基因组分析的。我们研究了果蝇的整体基因表达，并报告了X染色体基因在配偶中相对高表达的戏剧性低表达。利用比较基因组学，我们发现这些相同的X染色体基因在冈比亚按蚊中的保守性特别差。这些数据表明，对于男性选择性表达的基因来说，X染色体是不受欢迎的位置。
Sex chromosomes are primary determinants of sexual dimorphism in many organisms. These chromosomes are thought to arise via the divergence of an ancestral autosome pair and are almost certainly influenced by differing selection in mates and females. Exploring how sex chromosomes differ from autosomes is highly amenable to genomic analysis. We examined global gene expression in Drosophila melanogaster and report a dramatic underrepresentation of X-chromosome genes showing high relative expression in mates. Using comparative genomics, we find that these same X-chromosome genes are exceptionally poorly conserved in the mosquito Anopheles gambiae. These data indicate that the X chromosome is a disfavored location for genes selectively expressed in males.