Measurement of myocardial infarction fraction using single photon emission computed tomography.
Measurement of myocardial infarction fraction using single photon emission computed tomography.
复制标题
使用单光子发射计算机断层扫描测量心肌梗死分数。
DOI：
10.1016/s0735-1097(85)80266-7
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发表时间：
1985
影响因子：
24
通讯作者：
Willerson,JT
中科院分区：
文献类型：
--
作者：
Wolfe,CL;Lewis,SE;Corbett,JR;Parkey,RW;Buja,LM;Willerson,JT
虽然梗死面积通常与急性心肌梗死后的预后相关，但梗死面积的绝对测量可能具有不同的预后意义，这取决于绝对左心室质量。为了验证单光子发射计算机断层扫描可以准确测量心肌梗死面积占左心室总质量的百分比（“梗死分数”）的假设，在21只狗的左前降支或回旋支冠状动脉固定闭塞后24至48小时获得了铊-201和99 m锝焦磷酸断层扫描图。病理梗死重量测量为未显示氯化三苯基四唑染色的心肌质量。根据左心室体积元素（体素）总数（显示锝-99 m焦磷酸盐摄取）x体素尺寸（[0.476 cm]3）×心肌比重（1.05 g/cm 3）计算锝-99 m焦磷酸盐闪烁成像梗死质量。以类似的方式使用铊-201和锝-99m焦磷酸盐扫描的叠加计算闪烁照相左心室质量。梗死分数=梗死体积/左室体积，单光子发射型计算机断层扫描（SPECT）测量的梗死体积与病理结果有良好的相关性（~（99）m-锝焦磷酸盐质量= 1.01 ×病理性梗死质量+0.96; r = 0.98），左心室质量（单光子发射计算机断层左室质量= 0.60 ×病理左室质量+ 37.4; r = 0.86）和“梗死分数”（单光子发射计算机断层扫描梗死分数= 1.09 ×病理梗死分数-1.7; r = 0.94）。总之，单光子发射计算机断层扫描与铊-201和锝-99m焦磷酸盐可以提供准确的测定梗死质量，左心室质量和“梗死分数”在急性犬心肌梗死。
Although infarct size correlates generally with prognosis after acute myocardial infarction, an absolute measure of infarct size may have differing prognostic significance depending on absolute left ventricular mass. To test the hypothesis that single photon emission computed tomography can accurately measure myocardial infarct size as a percent of total left ventricular mass (“infarction fraction”), thallium-201 and technetium-99m pyrophosphate tomograms were acquired in 21 dogs 24 to 48 hours after fixed occlusion of the left anterior descending or circumflex coronary artery. Pathologic infarct weight was measured as the myocardial mass that showed no staining with triphenyltetrazolium chloride. Scintigraphic infarct mass by technetium-99m pyrophosphate was calculated from the total number of left ventricular volume elements (voxels) demonstrating technetium-99m pyrophosphate uptake x voxel dimension ([0.476 cm]3) × specific gravity of myocardium (1.05 g/cm3). Scintigraphic left ventricular mass was calculated in a similar fashion using an overlay of the thallium-201 and technetium-99m pyrophosphate scans. The “infarction fraction” was calculated as: infarction fraction = infarct mass/left ventricular mass.There was good correlation between single photon emission computed tomography and pathologic measurements of infarct mass (technetium-99m pyrophosphate mass = 1.01 × pathologic infarct mass + 0.96; r = 0.98), left ventricular mass (single photon emission computed tomographic left ventricular mass = 0.60 × pathologic left ventricular mass + 37.4; r = 0.86) and “infarction fraction” (single photon emission computed tomographic infarction fraction = 1.09 × pathologic infarction fraction − 1.7; r = 0.94). In conclusion, single photon emission computed tomography with thallium-201 and technetium-99m pyrophosphate can provide accurate determinations of infarct mass, left ventricular mass and “infarction fraction” in acute canine myocardial infarction.