Synthesis and characterization of carbon dots derived from compounds containing thioureas and thiazole rings
Synthesis and characterization of carbon dots derived from compounds containing thioureas and thiazole rings
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DOI：
10.1016/j.colsurfa.2023.131522
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发表时间：
2023-07
期刊：
影响因子：
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通讯作者：
Suhair M. S. Jambi;Jiuyan Chen;Wei Zhang;Shiwei Fu;Yiqun Zhou;Justin B. Domena;N. Brejcha;Fuwu Zhang;R. Leblanc
中科院分区：
文献类型：
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作者：
Suhair M. S. Jambi;Jiuyan Chen;Wei Zhang;Shiwei Fu;Yiqun Zhou;Justin B. Domena;N. Brejcha;Fuwu Zhang;R. Leblanc
以治疗性化合物为前体合成碳量子点（CD）是CD在药物递送和疾病治疗中应用的新趋势，它同时利用纳米颗粒和治疗性分子的优点，而不需要进一步修饰。含有硫脲和噻唑环的化合物在生物学应用中已被广泛研究，例如抗糖尿病、抗癌、抗微生物、抗病毒和抗真菌活性。然而，以该类化合物为前体合成环糊精的研究还未见报道。本研究成功地合成了4种由1-（苯并[d]噻唑-2-基）-3-苯基硫脲（H2 PhT）、N-乙基-N′-（4′-甲基噻唑-2 ′-基）硫脲（H2 EMT）、N-苯基-N′-（4′-甲基噻唑-2 ′-基）硫脲（H2 PhMT）和N-甲基-N′-（4′-甲基噻唑-2 ′-基）硫脲（H2 MMT）衍生的环糊精，并对其结构进行了表征。紫外-可见吸收光谱、荧光光谱、傅里叶变换红外光谱、原子力显微镜、zeta电位和热重分析表明，这四种环糊精的分子量均小于10 nm。H2 PhT-CD、H2 EMT-CD和H2 PhMT-CD在约440 nm处具有激发非依赖性PL发射，而H2 MMT-CD表现出激发依赖性PL发射性质。CD的结构性质表明在相应的H2 PhT-CD、H2 EMT-CD、H2 PhMT-CD和H2 MMT-CD中存在可能与H2 PhT、H2 EMT、H2 PhMT和H2 MMT的治疗效果相关的某些部分。此外，所有四个CD家族都具有轻微的正电荷或负电荷，这有利于它们对细胞的亲和力。本研究的结果可以为了解这些CD在未来研究中治疗糖尿病，癌症和感染的潜在应用提供知识。
Synthesizing carbon dots (CDs) using therapeutic compounds as precursors is a new trend in the applications of CDs in drug delivery and disease treatment by leveraging the advantages of nanoparticles and therapeutic molecules simultaneously, without the need of further modifications. Compounds containing thioureas and thiazole rings have been extensively studied in biological applications such as antidiabetic, anticancer, antimicrobial, antiviral and antifungal activities. However, the research using such compounds as precursors to synthesize CDs has not been reported. In this study, four types of CDs derived from 1-(benzo[d]thiazol-2-yl)− 3-phenylthiourea (H2PhT), N-ethyl-N′-(4′-methylthiazol-2′-yl) thiourea (H2EMT), N-phenyl-N′-(4′-methylthiazol-2′-yl)thiourea (H2PhMT) or N-methyl-N′-(4′-methylthiazol-2′-yl)thiourea(H2MMT) were successfully prepared and characterized. The UV–vis absorption, fluorescence, and Fourier-transform infrared (FTIR) spectroscopies, atomic force microscopy (AFM), zeta potential measurements and thermogravimetric analysis (TGA) suggested that these four families of CDs are all less than 10 nm. H2PhT-CDs, H2EMT-CDs, and H2PhMT-CDs possess excitation-independent PL emission at around 440 nm, while H2MMT-CDs exhibit excitation-dependent PL emission property. The structural properties of CDs indicate the presence of certain moieties that may be associated with the therapeutic effects of H2PhT, H2EMT, H2PhMT and H2MMT in the corresponding H2PhT-CDs, H2EMT-CDs, H2PhMT-CDs and H2MMT-CDs. Moreover, all four families of CDs possess a slightly positive or negative charge, which benefits their affinities to cells. The results in this study could provide the knowledge in understanding the potential applications of these CDs in the treatment of diabetes, cancer, and infections in future research.