Prolongation of cardiac allograft survival in rats by liposome-encapsulated methylprednisolone.
Prolongation of cardiac allograft survival in rats by liposome-encapsulated methylprednisolone.
复制标题
脂质体封装的甲基强的松龙可延长大鼠同种异体心脏移植物的存活率。
DOI：
10.1097/00007890-199409150-00021
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发表时间：
1994
期刊：
影响因子：
6.2
通讯作者：
Kupiec-Weglinski,JW
中科院分区：
文献类型：
--
作者：
Binder,J;Mishina,EV;Jusko,WJ;Kupiec-Weglinski,JW
1994年9月答复。在SCID小鼠模型的范围内，CD4细胞不能提供与CD8 CTL相当的保护。因此，我们支持在体内使用CD8" T细胞克隆来控制病毒感染的细胞。在临床移植环境中，CD8“T细胞克隆可以被预先筛选，并选择对病毒感染而不是未感染的供体和受体来源的目标具有强活性的CD8”T细胞克隆。克隆可以在免疫抑制个体无移植物抗宿主病的情况下提供病毒特异性保护。作者感谢VE Turner提供的HLA分型数据，感谢CM Rooney、MK Brenner、ME Eichelberger和J. Gilbert对手稿的有益讨论和批判性阅读。
September 1994 sponse. Within the confines of the SCID mouse model, CD4" cells do not provide protection comparable to that of CD8" CTL. We therefore support the use of CD8" T cell clones for the control of virus-infected cells in vivo. In the clinical trans-plant setting, CD8" T cell clones may be prescreened and selected for strong activity toward virus-infected, but not uninfected, targets of donor and recipient origin. Clones may then provide virus-specific protection in the absence of graftversus-host disease in the immunosuppressed individual.Acknowledgments. The authors thank VE Turner for HLA typing data and CM Rooney, MK Brenner, ME Eichelberger, and J. Gilbert for useful discussions and critical reading of the manuscript.