Synthesis, structural characterization, and antitumor activity of palladium(II) complexes containing a sugar unit
Synthesis, structural characterization, and antitumor activity of palladium(II) complexes containing a sugar unit
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DOI：
10.1016/j.bmcl.2004.02.095
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发表时间：
2004-05-17
影响因子：
2.7
通讯作者：
Yano, S
中科院分区：
文献类型：
--
作者：
Brudziñska, I;Mikata, Y;Yano, S
制备了六种含糖单位（d -葡萄糖、d -半乳糖、d -甘露糖、d -木糖和麦芽糖）的顺铂衍生物钯（II）配合物。通过核磁共振光谱、元素分析、质谱和x射线晶体学对配合物的结构特征进行了表征。这些复合物已在小鼠体内对P388细胞进行了细胞毒性测试。所有Pd化合物显然都是无毒的。麦芽糖衍生物在400mg/kg剂量下的T/C值为120%，表明该化合物可能具有抗肿瘤活性。(C) 2004 Elsevier Ltd.版权所有。
Six palladium(II) complexes as cisplatin derivatives with a sugar unit (D-glucose, D-galactose, D-mannose, D-Xylose, and maltose) have been prepared. The structural features of the complexes have been characterized by NMR spectroscopy, elemental analysis, mass spectroscopy, and X-ray crystallography. The complexes have been tested for in vivo cytotoxicity against P388 cells implanted in mice. All of Pd compounds are apparently nontoxic. A T/C value of 120% was obtained for maltose derivative at the dose of 400mg/kg, which indicates that the compound may be endowed with antitumor activity. (C) 2004 Elsevier Ltd. All rights reserved.