Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein
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DOI：
10.1200/jco.2015.64.1357
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发表时间：
2016-05-20
影响因子：
45.3
通讯作者：
Lee, Jeffrey E.
中科院分区：
文献类型：
--
作者：
Fang, Shenying;Sui, Dawen;Lee, Jeffrey E.
PurposeTo评估25-羟基维生素D水平（维生素D）和结果之间的关联措施，在黑色素瘤患者评价后，控制全身炎症反应（SIR）的基础上，同时C-反应蛋白（CRP）measurement.Materials和MethodsPlasma样本从1,042前瞻性观察黑色素瘤患者进行了维生素D和CRP测定。确定人口统计学和CRP与维生素D的相关性，然后确定维生素D与抽血日期的阶段和结果测量之间的相关性。如果维生素D水平为30至100 ng/mL，则认为维生素D水平足够。Kaplan-Meier和考克斯回归分析进行results.ResultsThe中位数维生素D水平为25.0 ng/mL。中位随访时间为7.1年。较低的维生素D与秋冬季节的抽血有关（P
PurposeTo evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.Materials and MethodsPlasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.ResultsThe median vitamin D level was 25.0 ng/mL. The median follow-up time was 7.1 years. A lower vitamin D was associated with the blood drawduring fall/winter months (P