COMMON GENETIC MECHANISMS IN ALCOHOL, DRUG, AND MENTAL DISORDER COMORBIDITY
COMMON GENETIC MECHANISMS IN ALCOHOL, DRUG, AND MENTAL DISORDER COMORBIDITY
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DOI：
10.1016/0376-8716(95)01151-n
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发表时间：
1995-08-01
影响因子：
4.2
通讯作者：
LABUDA, MC
中科院分区：
文献类型：
--
作者：
PICKENS, RW;SVIKIS, DS;LABUDA, MC
对63对同卵双生子(MZ)和67对同卵双生子(DZ)的药物和精神障碍进行了评估。当先证者患有DSM-III药物或精神障碍时，DSM-III酒精依赖在男性中是可遗传的，但当先证者仅有酒精依赖时则不是。对于男性，先证者的酒精依赖与同卵双胞胎的某些精神和药物障碍之间的交叉MZ显著高于交叉DZ。相比之下，女性的双胞胎内相关性高于跨MZ相关性，而酒精依赖与所有精神和药物障碍之间的交叉MZ和交叉DZ相关性相似。这些结果表明，在流行病学调查中，男性中酒精与某些药物和精神障碍之间的共病可能部分是由于遗传影响。
Comorbid drug and mental disorders were assessed in 63 monozygotic (MZ) and 67 dizygotic (DZ) twin pairs. DSM-III alcohol dependence was heritable in males when probands had a comorbid DSM-III drug or mental disorder but not when probands had only alcohol dependence. For males, significantly higher cross-MZ than cross-DZ correlations were found between alcohol dependence in probands and certain mental and drug disorders in cotwins. In contrast, females showed higher within-twin than cross-MZ correlations and similar cross-MZ and cross-DZ correlations between alcohol dependence and all mental and drug disorders. These results suggest comorbidity between alcohol and certain drug and mental disorders in males in epidemiological surveys may be due in part to genetic influences.