α Foetoprotein and serum albumin show sequence homology
α Foetoprotein and serum albumin show sequence homology
复制标题
DOI：
10.1038/260804a0
复制
发表时间：
1976-04
期刊：
影响因子：
64.8
通讯作者：
E. Ruoslahti;W. Terry
中科院分区：
文献类型：
--
作者：
E. Ruoslahti;W. Terry
α胎蛋白（AFP）是一种主要的胎儿血浆蛋白，由卵黄囊和肝脏产生。除了肝癌和畸胎瘤等肿瘤患者外，成人中其浓度极低。AFP的分子量为70000，由一条多肽链组成，含有约4%的碳水化合物。甲胎蛋白和白蛋白化学性质的相似性，以及它们在血清中的浓度高且呈负相关的事实，使人们认为甲胎蛋白可能是胎儿白蛋白的对应物。我们已经确定了人AFP片段的氨基酸序列，并发现这些片段与白蛋白序列具有同源性。
α FOETOPROTEIN (AFP) is a major plasma protein of the foetus1, where it is produced by the yolk sac and the liver2. In adults its concentration is extremely low3except in patients with tumours such as hepatomas and teratomas4,5. AFP has a molecular weight of 70,000, consists of a single polypeptide chain and contains about 4% carbohydrate6. The similarity of the chemical properties of AFP and albumin and the fact that their concentrations in the serum are high and inversely related7has led to the suggestion8that AFP may be a foetal counterpart of albumin. We have determined amino acid sequences of fragments of human AFP and found homology between these and the albumin sequence.