EXPRESSION OF THYROID-HORMONE RECEPTOR ISOFORMS IN RAT OLIGODENDROCYTE CULTURES - EFFECT OF 3,5,3'-TRIIODO-L-THYRONINE
EXPRESSION OF THYROID-HORMONE RECEPTOR ISOFORMS IN RAT OLIGODENDROCYTE CULTURES - EFFECT OF 3,5,3'-TRIIODO-L-THYRONINE
复制标题
DOI：
10.1016/0304-3940(94)90868-0
复制
发表时间：
1994-07-18
影响因子：
2.5
通讯作者：
SARLIEVE, LL
中科院分区：
文献类型：
--
作者：
BAAS, D;FRESSINAUD, C;SARLIEVE, LL
3,5,3'-Triiodo-L-thyronine (T-3) acts at the genomic level by interacting with nuclear T-3 receptors (T(3)Rs). We have used double immunostaining to follow the expression of T(3)Rs and oligodendrocytes (OL) lineage markers in rat secondary cultures consisting of 85-90% OL. Using antibodies against different synthetic peptides of T(3)Rs (alpha common: alpha 1 + alpha 2 and pi) we find that alpha-T(3)R is expressed in both O-2A progenitors and in mature OL, while beta 1-T(3)R is expressed only in mature OL. In cultured OL, beta 1-T(3)R mRNA is upregulated the most by T-3. OL exhibit more numerous and longer processes when treated by T-3.
