Clinical use of the insulin infusion pump in 100 patients with type I diabetes.
Clinical use of the insulin infusion pump in 100 patients with type I diabetes.
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胰岛素输注泵在100例I型糖尿病患者中的临床应用
DOI：
10.1056/nejm198208263070901
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
W. J. Steenrod
中科院分区：
文献类型：
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作者：
R. Mecklenburg;J. Benson;N. Becker;P. L. Brazel;P. Fredlund;R. Metz;R. Nielsen;C. Sannar;W. J. Steenrod
我们研究了胰岛素泵疗法对年龄在18岁到69岁之间的胰岛素依赖型糖尿病患者的疗效，方法是将100名患者使用胰岛素泵疗法所获得的代谢控制与之前通过常规胰岛素疗法所获得的代谢控制进行比较。在泵治疗期间对患者进行长达15个月的随访。空腹和非空腹血糖水平(平均值+/-S.E.M.)泵治疗1个月后分别由治疗前的2 0 1+/-6和2 13+/-6 mg/分升降至15 8+/-5和145+/-3 mg/分升(P<0.001.0 5)。93名患者的血糖控制有所改善；71%的患者在6个月后的平均血糖浓度为150毫克/分升(8.3 mmol/升)或更低。在进行了后续检测的88名患者中，44%的患者糖化血红蛋白值恢复正常。在超过500个病人月中，发生了4次酮症酸中毒和5次严重低血糖。3例患者放弃了泵治疗。我们的结论是，胰岛素泵疗法是可以被患者接受的，它可以成功地应用于临床实践和大规模研究。
We investigated the efficacy of insulin-pump therapy in insulin-dependent diabetics, aged 18 to 69 years, by comparing the metabolic control achieved in 100 patients using this technique with that previously obtained by conventional insulin therapy. Patients were followed during pump therapy for as long as 15 months. Fasting and nonfasting blood glucose levels (mean +/- S.E.M.) decreased from 201 +/- 6 and 213 +/- 6 mg per deciliter (11.2 +/- 0.3 and 11.8 +/- 0.3 mmol per liter), respectively, to 158 +/- 5 and 145 +/- 3 mg per deciliter (8.77 +/- 0.3 and 8.05 +/- 0.2 mmol per liter) after one month of pump therapy (P less than 0.001). Ninety-three patients had improved blood sugar control; 71 per cent had a mean blood sugar concentration of 150 mg per deciliter (8.3 mmol per liter) or less after six months. Glycosylated hemoglobin values became normal in 44 per cent of 88 patients who had follow-up determinations. In over 500 patient-months there were four episodes of ketoacidosis and five episodes of serious hypoglycemia. Three patients abandoned pump therapy. We conclude that insulin-pump therapy is acceptable to patients and that it can be successfully applied to clinical practice and large-scale research studies.