Association of donor and recipient SUMO4 rs237025 genetic variant with new-onset diabetes mellitus after liver transplantation in a Chinese population
Association of donor and recipient SUMO4 rs237025 genetic variant with new-onset diabetes mellitus after liver transplantation in a Chinese population
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供体和受体 SUMO4 rs237025 遗传变异与中国人群肝移植后新发糖尿病的关系
DOI：
10.1016/j.gene.2017.06.060
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发表时间：
2017
期刊：
影响因子：
3.5
通讯作者：
Peng Zhihai
中科院分区：
文献类型：
--
作者：
Zhang Tao;Liu Yuan;Hu Yibo;Zhang Xiaoqing;Zhong Lin;Fan Junwei;Peng Zhihai
新发糖尿病（NODM）是肝移植术后常见的并发症。小泛素样修饰物4（SUMO 4）rs 237025多态性与2型糖尿病（T2 DM）相关。在这项研究中，我们的目的是评估供体和受体的SUMO 4 rs 237025多态性与NODM和长期后果的NODM后LT.MethodsA共126例肝移植患者参加了这项研究。结果SUMO 4 rs 237025多态性与肝移植后NODM的发生有显著相关性。多因素分析显示，受者年龄> 50岁，肝移植后1个月他克莫司谷浓度> 10 ng/mL，供受者rs 237025基因变异，供、受者联合rs 237025基因变异是NODM的独立预测因素。受试者工作特征曲线下面积（AUROC）分析表明，含有供体和受体rs 237025多态性组合的模型的预测能力高于临床模型（p = 0.046）。此外，Kaplan-Meier生存分析表明，NODM与显着较差的患者生存率相比，非NODM patients（p = 0.041）。ConclusionsBoth供体和受体SUMO 4 rs 237025多态性有助于发展的NODM LT和NODM是一种常见的并发症，对患者的生存率产生负面影响。
Backgrounds & aimsNew-onset diabetes mellitus (NODM) is a common complication after liver transplantation (LT). The small ubiquitin-like modifier 4 (SUMO4) rs237025 polymorphism has been reported to be associated with type 2 diabetes mellitus (T2DM). In this study, we aimed to evaluate the association of donor and recipient SUMO4 rs237025 polymorphisms with NODM and the long-term consequences of NODM after LT.MethodsA total of 126 liver transplant patients were enrolled in the study. One single nucleotide polymorphism, SUMO4 rs237025, was genotyped in both donors and recipients.ResultsBoth donor and recipient SUMO4 rs237025 polymorphisms were found to be significantly associated with NODM after LT. In multivariate analysis, recipient age > 50 years, tacrolimus trough concentrations > 10 ng/mL at 1 month after LT, donor and recipient rs237025 genetic variant, and the combined donor and recipient rs237025 genetic variant were independent predictive factors of NODM. Area under the receiver operating characteristic curve (AUROC) analysis indicated the higher predictive ability of the model containing combined donor and recipient rs237025 polymorphisms than the clinical model (p = 0.046). Furthermore, Kaplan-Meier survival analysis demonstrated that NODM was related to significantly poorer patient survival in comparison with non-NODM patients (p = 0.041).ConclusionsBoth donor and recipient SUMO4 rs237025 polymorphisms contribute to the development of NODM after LT and NODM is a frequent complication that negatively affects patient survival.