For whom the bell (curve) tolls: Cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship
For whom the bell (curve) tolls: Cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship
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DOI：
10.1016/j.psyneuen.2013.01.001
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发表时间：
2013-09-01
影响因子：
3.7
通讯作者：
Schaechinger, Hartmut
中科院分区：
文献类型：
--
作者：
Schilling, Thomas M.;Koelsch, Monika;Schaechinger, Hartmut
压力和皮质醇通常被认为会损害陈述性记忆提取，尽管也有相反的结果。剂量依赖性效应以及基因组和非基因组皮质醇效应之间的差异可能是造成这些差异的原因。本实验的目的是评估静脉注射皮质醇剂量递增对人类社会相关信息线索回忆的非基因组效应。40名参与者（年龄范围20-30岁; 20名女性）学习了具有中性面部表情的男性面孔与积极或消极社会行为描述之间的关联，并在一周后进行了线索回忆范式测试。根据受试者间设计，在测试前8分钟给予递增剂量的皮质醇（0、3、6、12、24 mg）。唾液皮质醇水平和回忆性能之间的倒U形剂量反应关系进行了观察，与唾液皮质醇的中度升高导致最佳的回忆性能。这是第一个在人类中进行的研究，证明皮质醇通过剂量依赖性的非基因组机制快速调节陈述性记忆提取，该机制遵循倒U形曲线。我们的结果进一步强调了快速皮质醇效应对人类认知的重要性。(C)2013爱思唯尔有限公司保留所有权利。
Stress and cortisol are generally considered to impair declarative memory retrieval, although opposite results have also been reported. Dose-dependent effects and differences between genomic and non-genomic cortisol effects are possible reasons for these discrepancies. The aim of the current experiment was to assess the non-genomic effects of escalating doses of intravenous cortisol on cued recall of socially relevant information in humans. 40 participants (age range 20-30 years; 20 females) learned associations between male faces with a neutral facial expression and descriptions of either positive or negative social behaviors and were tested one week later in a cued recall paradigm. Escalating doses of cortisol (0, 3, 6, 12, 24 mg) were administered 8 min before testing according to a between-subjects design. An inverted U-shaped dose-response relationship between salivary cortisol levels and recall performance was observed, with moderate elevation of salivary cortisol resulting in the best recall performance. This is the first study in humans demonstrating that cortisol rapidly modulates declarative memory retrieval via a dose-dependent, non-genomic mechanism that follows an inverted U-shaped curve. Our result further emphasizes the importance of fast cortisol effects for human cognition. (C) 2013 Elsevier Ltd. All rights reserved.