Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells
Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells
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DOI：
10.1002/bies.201100090
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发表时间：
2012-04-01
期刊：
影响因子：
4
通讯作者：
Wang, Hongyan
中科院分区：
文献类型：
--
作者：
Chang, Kai Chen;Wang, Cheng;Wang, Hongyan
平衡干细胞的自我更新和分化是干细胞和癌症生物学中的重要问题。近年来，果蝇成神经细胞（NB）、神经干细胞已成为研究干细胞自我更新和肿瘤发生的良好模型。了解神经干细胞不对称分裂的缺陷如何导致肿瘤形成是非常有趣的。在这里，我们回顾了果蝇NBs的不对称分裂和自我更新控制的最新进展。我们总结了细胞不对称分裂的分子机制，并讨论了不对称分裂的缺陷如何导致肿瘤的形成。不对称机制中各种蛋白质的功能获得或功能丧失可驱动NB过度生长和肿瘤形成。这些蛋白质控制不对称的蛋白质定位或有丝分裂纺锤体方向的NB。我们还讨论了其他机制的脑肿瘤抑制是不对称分裂的控制。
Balancing self-renewal and differentiation of stem cells is an important issue in stem cell and cancer biology. Recently, the Drosophila neuroblast (NB), neural stem cell has emerged as an excellent model for stem cell self-renewal and tumorigenesis. It is of great interest to understand how defects in the asymmetric division of neural stem cells lead to tumor formation. Here, we review recent advances in asymmetric division and the self-renewal control of Drosophila NBs. We summarize molecular mechanisms of asymmetric cell division and discuss how the defects in asymmetric division lead to tumor formation. Gain-of-function or loss-of-function of various proteins in the asymmetric machinery can drive NB overgrowth and tumor formation. These proteins control either the asymmetric protein localization or mitotic spindle orientation of NBs. We also discuss other mechanisms of brain tumor suppression that are beyond the control of asymmetric division.