Persistent effects of COVID-19 in patients hospitalized during the first wave of the pandemic: The impact of persistent fatigue on quality of life in a cross-sectional study.
Persistent effects of COVID-19 in patients hospitalized during the first wave of the pandemic: The impact of persistent fatigue on quality of life in a cross-sectional study.
复制标题
COVID-19 对第一波大流行期间住院患者的持续影响：横断面研究中持续疲劳对生活质量的影响。
DOI：
10.1002/jmv.28491
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发表时间：
2023
影响因子：
12.7
通讯作者：
Moran,LaurenV
中科院分区：
文献类型：
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作者：
Skinner,JosephP;Moran,LaurenV
COVID-19在急性感染后很长一段时间内都会影响身体和心理健康。在这项描述性研究中，我们对2020年4月至5月期间因COVID-19住院的48名患者进行了关于住院后COVID-19经历的采访。参与者的平均年龄为51.1（±11.91）岁（范围25-65岁），其中26名（54.2%）为男性。个体平均有1.2（±0.94）例与更严重的COVID-19相关的合并症，其中高血压（37.5%）最常见。19名（39.6%）患者需要在重症监护室接受治疗。参与者在出院后的中位时间为553天（IQR，405.5 - 589.0）。37名（77.1%）受试者在访谈时有5种或以上持续症状，只有3名（6.3%）没有症状。最常报告的持续症状是疲劳（79.2%）、呼吸困难（68.8%）和肌无力（60.4%）。39名（81.3%）参与者的生活质量较差，8名（16.7%）的创伤后应激障碍（PTSD）评分在临床诊断范围内。对于多变量分析，急性COVID-19期间的症状数量可显著预测持续性疲劳（t= 4.4，p < 0.001）。急性COVID-19期间的症状数量也与持续性呼吸困难显著相关（t= 3.4，p = 0.002）。COVID-19后Chalder疲劳量表得分较高与生活质量差（t= 2.6，p = 0.01）和PTSD精神病学（t= 2.9，p = 0.008）显著相关。需要更多的研究来强调长期COVID患者在出院后很长时间内需要的广泛资源。
COVID‐19 can affect physical and mental health long after acute infection. In this descriptive study, 48 individuals hospitalized for COVID‐19 between April and May 2020 were interviewed regarding their experience with COVID‐19 after hospitalization. The mean age of participants was 51.1 (±11.91) years (range 25–65 years) and 26 (54.2%) were men. Individuals had a mean of 1.2 (±0.94) comorbidities associated with more severe COVID‐19, with hypertension (37.5%) being most common. Nineteen (39.6%) individuals required treatment in the intensive care unit. Participants were interviewed a median time of 553 days (IQR, 405.5−589.0) after discharge from the hospital. Thirty‐seven (77.1%) individuals had 5 or more persistent symptoms at time of interview with only 3 (6.3%) experiencing none. The most reported persistent symptoms were fatigue (79.2%), difficulty breathing (68.8%), and muscle weakness (60.4%). Poor quality of life was experienced by 39 (81.3%) participants and 8 (16.7%) had a posttraumatic stress disorder (PTSD) score within the clinical range for diagnosis. For multivariable analyses, persistent fatigue was significantly predicted by number of symptoms during acute COVID‐19 (t= 4.4,p< 0.001). Number of symptoms during acute COVID‐19 was also significantly associated with persistent dyspnea (t= 3.4,p= 0.002). Higher scores on the Chalder fatigue scale after COVID‐19 was significantly associated with poor quality of life (t= 2.6,p= 0.01) and PTSD symptomatology (t= 2.9,p= 0.008). More research is needed to highlight the wide range of resources those suffering from Long COVID require long after discharge.