The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence
The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence
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DOI：
10.1111/acer.12141
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发表时间：
2013-10-01
影响因子：
3.2
通讯作者：
Nicholas, Christian L.
中科院分区：
文献类型：
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作者：
Chan, Julia K. M.;Trinder, John;Nicholas, Christian L.
背景饮酒在青春期后期很普遍，然而，对这一群体的睡眠影响知之甚少。在成年人中，酒精会降低睡眠起始潜伏期（SOL）和睡眠效率（SE），并增加睡眠起始后觉醒（WASO）。它还增加了上半夜的慢波睡眠（SWS），减少了快速眼动（REM）睡眠，下半夜则相反。酒精对青春期后期睡眠的影响很有趣，因为这个年龄组的酒精消费量急剧增加，中枢神经系统也发生了显着的发育变化。这项研究调查了酒精对18至21岁男性和女性睡眠结构的影响，以及先前报道的睡眠结构影响是否可能是睡眠周期长度变化的人为结果。（12名女性）健康的18至21岁轻度社交饮酒者（19.11.0岁）经历了2种情况：前叶醇（目标呼吸酒精浓度[BAC] 0.10%）和安慰剂在受控条件下给药，然后进行标准多导睡眠图。熄灯时的平均BAC为0.084 +/-0.016%。在不同条件下，卧床时间、总睡眠时间和SOL（均p>0.05）没有差异。然而，在酒精条件下，REM（p=0.011）较少，第二阶段睡眠（p=0.035）较多。此外，酒精增加SWS（p=0.02）和减少REM睡眠（p
BackgroundAlcohol consumption is prevalent in late adolescence; however, little is known about its effect on sleep in this group. In mature adults, alcohol decreases sleep onset latency (SOL) and sleep efficiency (SE) and increases wake after sleep onset (WASO). It also increases slow wave sleep (SWS) and decreases rapid eye movement (REM) sleep in the first half of the night, with the inverse occurring in the second half. Alcohol's effect on sleep during late adolescence is of interest given that this age group shows both dramatic increases in alcohol consumption and significant developmental changes in the central nervous system. This study examined the effect of alcohol on sleep architecture in women and men aged 18 to 21years and whether previously reported sleep architecture effects may have been as an artificial result of changes to sleep cycle length.MethodsTwenty-four (12 women) healthy 18- to 21-year-old light social drinkers (19.11.0years) underwent 2 conditions: presleep alcohol (target breath alcohol concentration [BAC] 0.10%) and placebo-administered under controlled conditions, followed by standard polysomnography.ResultsIn the alcohol condition, mean BAC at lights out was 0.084 +/- 0.016%. Time in bed, total sleep time, and SOL (all p>0.05) did not differ between conditions. However, there was less REM (p=0.011) and more stage-2 sleep (p=0.035) in the alcohol condition. Further, alcohol increased SWS (p=0.02) and decreased REM sleep (p