SPLEEN EMPTYING AND VENOUS HEMATOCRIT IN HUMANS DURING EXERCISE
SPLEEN EMPTYING AND VENOUS HEMATOCRIT IN HUMANS DURING EXERCISE
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DOI：
10.1152/jappl.1993.74.3.1024
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发表时间：
1993-03-01
影响因子：
3.3
通讯作者：
NIELSEN, SL
中科院分区：
文献类型：
--
作者：
LAUB, M;HVIDJACOBSEN, K;NIELSEN, SL
在剧烈运动等剧烈运动条件下，脾可能会将聚集的红细胞释放到普通循环中。我们对脾的这种储藏功能的了解大多来自动物研究，而脾对人类循环血液量的贡献一直被认为是无关紧要的。记录踏车运动至最大负荷时人体脾内红细胞含量。在5名正常成人中，静脉注射标记的自体红细胞，受试者被放在自行车上，背对着聚焦在脾上的伽马相机。在递增负荷运动中，脾红细胞含量呈线性下降，最大负荷时降至仰卧休息时的34.2%(44-26%)。同时，血浆中去甲肾上腺素和肾上腺素逐渐增加，而神经肽Y仅在最大运动量时增加。红细胞压积从平均值44.6升至48，但来自脾的红细胞输注只是部分解释了体力活动中红细胞压积升高的原因。
The spleen may release pooled erythrocytes to the general circulation during strenuous conditions such as heavy exercise. Most of our knowledge of this reservoir function of the spleen derives from animal studies, and the splenic contribution to the circulating blood volume in humans has been regarded as unimportant. We recorded the erythrocyte content in the human spleen during graded bicycle exercise to maximal working capacity. In five normal adults Tc-99m-labeled autologous erythrocytes were injected intravenously, and the subjects were placed on bicycles with the back against a gamma camera focusing on the spleen. During increasing exercise the splenic erythrocyte content decreased linearly, and at maximal work load it had been reduced to a mean of 34.2% (range 44-26%) of the initial count rate at supine rest. Concomitantly norepinephrine and epinephrine in plasma increased gradually, whereas neuropeptide Y increased only at maximal exercise. A rise in hematocrit from a mean of 44.6 to 48 was observed, but the autotransfusion of erythrocytes from the spleen only partly explains the rise in hematocrit during physical activity.