The differential interfacial tension hypothesis (DITH): a comprehensive theory for the self-rearrangement of embryonic cells and tissues
The differential interfacial tension hypothesis (DITH): a comprehensive theory for the self-rearrangement of embryonic cells and tissues
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DOI：
10.1115/1.1449491
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发表时间：
2002-04-01
影响因子：
1.7
通讯作者：
Brodland, GW
中科院分区：
文献类型：
--
作者：
Brodland, GW
本文提出了一个关于胚胎细胞和组织自我重排的综合理论，即微分界面张力假说（DITH）。这些重排包括胚胎细胞异型聚集体的分选、混合和棋盘图案的形成，以及组织的全部或部分吞噬、分离和解离。这一基础广泛的理论解释了所有目前已知的细胞骨架成分和细胞粘附机制的作用。该理论用于推导上面训练的细胞和组织重排的条件。涉及两种或多种细胞类型的基于有限元的计算机模拟证实了这些条件。
A comprehensive theory, herein named the Differential Interfacial Tension Hypothesis (DITH), for the self-rearrangement of embryonic cells and tissues is presented. These rearrangements include sorting, mixing and formation of checkerboard patterns in heterotypic aggregates of embryonic cells, and total or partial engulfment, separation and dissociation of tissues. This broadly-based theory accounts for the action of all currently known cytoskeletal components and cell adhesion mechanisms. The theory is used to derive conditions for the cell and tissue rearrangements trained above. Finite element-based computer simulations involving two or more cell types confirm these conditions.