Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study
Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study
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DOI：
10.3174/ajnr.a6646
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发表时间：
2020-08-01
影响因子：
3.5
通讯作者：
Yang, J. Y-M
中科院分区：
文献类型：
--
作者：
Arrigoni, F.;Peruzzo, D.;Yang, J. Y-M
作者回顾性分析了 50 名患有不同多小脑回 (n = 42) 和无脑畸形 (n = 8) 亚型的患者（平均年龄 8.3 岁）。将每位患者重建的纤维方向编码彩色图和 6 个不同的白质束与从 7 个年龄匹配的健康对照 WM 模板重建的相应图像进行视觉比较。作者证明了多小脑回和无脑畸形患者存在一系列白质束结构异常。白质束受累的模式与多小脑回和无脑畸形亚群、分布以及可能的潜在病因有关。 背景和目的：多小脑回和无脑畸形可能与基础白质束的异常组织有关，迄今为止很少对此进行研究。我们的目的是使用约束球形解卷积（一种用于白质纤维束成像重建的多纤维扩散磁共振成像建模技术）来表征多小脑回和无脑畸形的白质束组织。材料和方法：我们回顾性分析了 50 名不同多小脑回 (n= 42) 和无脑畸形 (n= 8) 亚型的患者（平均年龄，8.3 +/- 5.4 岁；范围，1.4-21.2 岁；27 名男性）。将每位患者重建的纤维方向编码彩色图和 6 个不同的白质束与从 7 个年龄匹配的健康对照 WM 模板重建的相应图像进行视觉比较。每个白质束均由 2 位经验丰富的儿科神经放射科医生进行评估，并根据结构异常的严重程度（从白质束缺失到增厚）达成一致评分。结果按不同的多小脑回和无脑畸形亚组进行总结。结果：与多小脑回患者相比，无脑畸形患者有更多异常的白质束（79.2% vs 37.3%）。在无脑畸形中，所有研究的白质束均发现结构异常。在多小脑回中，最常受影响的白质束是扣带回、上纵束、下纵束和视放射-后放射冠。上纵束和扣带回异常的严重程度与多小脑回的分布和范围相关。 3 名患者出现额枕上束增厚。结论：我们证明了多小脑回和无脑畸形患者存在一系列白质束结构异常。白质束受累的模式与多小脑回和无脑畸形亚组、分布以及可能的潜在病因有关。
The authors retrospectively reviewed 50 patients (mean age, 8.3 years) with different polymicrogyria (n= 42) and lissencephaly (n= 8) subtypes. The fiber direction-encoded color maps and 6 different white matter tracts reconstructed from each patient were visually compared with corresponding images reconstructed from 7 age-matched, healthy control WM templates. The authors demonstrated a range of white matter tract structural abnormalities in patients with polymicrogyria and lissencephaly. The patterns of white matter tract involvement are related to polymicrogyria and lissencephaly subgroups, distribution, and, possibly, their underlying etiologies.BACKGROUND AND PURPOSE: Polymicrogyria and lissencephaly may be associated with abnormal organization of the undelying white matter tracts that have been rarely investigated so far. Our aim was to characterize white matter tract organization in polymicrogyria and lissencephaly using constrained spherical deconvolution, a multifiber diffusion MR imaging modeling technique for white matter tractography reconstruction. MATERIALS AND METHODS: We retrospectively reviewed 50 patients (mean age, 8.3 +/- 5.4 years; range, 1.4-21.2 years; 27 males) with different polymicrogyria (n= 42) and lissencephaly (n= 8) subtypes. The fiber direction-encoded color maps and 6 different white matter tracts reconstructed from each patient were visually compared with corresponding images reconstructed from 7 age-matched, healthy control WM templates. Each white matter tract was assessed by 2 experienced pediatric neuroradiologists and scored in consensus on the basis of the severity of the structural abnormality, ranging from the white matter tracts being absent to thickened. The results were summarized by different polymicrogyria and lissencephaly subgroups. RESULTS: More abnormal-appearing white matter tracts were identified in patients with lissencephaly compared with those with polymicrogyria (79.2% versus 37.3%). In lissencephaly, structural abnormalities were identified in all studied white matter tracts. In polymicrogyria, the more frequently affected white matter tracts were the cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and optic radiation-posterior corona radiata. The severity of superior longitudinal fasciculus and cingulum abnormalities was associated with the polymicrogyria distribution and extent. A thickened superior fronto-occipital fasciculus was demonstrated in 3 patients. CONCLUSIONS: We demonstrated a range of white matter tract structural abnormalities in patients with polymicrogyria and lissencephaly. The patterns of white matter tract involvement are related to polymicrogyria and lissencephaly subgroups, distribution, and, possibly, their underlying etiologies.