FOXC2 promotes colorectal cancer proliferation through inhibition of FOX03a and activation of MAPK and AKT signaling pathways (Retracted Article)
FOXC2 promotes colorectal cancer proliferation through inhibition of FOX03a and activation of MAPK and AKT signaling pathways (Retracted Article)
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DOI：
10.1016/j.canlet.2014.07.008
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发表时间：
2014-10-10
期刊：
影响因子：
9.7
通讯作者：
Liao, Wen-Ting
中科院分区：
文献类型：
--
作者：
Cui, Yan-Mei;Jiang, Dan;Liao, Wen-Ting
FOXC 2的异常表达已在几种人类癌症中发现。然而，FOXC 2在结直肠癌（CRC）进展中的作用尚未得到很好的表征。在206例结直肠癌标本的分析中，我们发现FOXC 2的高表达和核定位与结直肠癌患者的侵袭性特征和不良生存率相关。FOXC 2通过激活MAPK和ART途径促进细胞增殖，随后下调p27，上调cyclin D1和p-FOXO 3a。此外，FOXC 2核定位是其促进细胞增殖所必需的。这些发现表明FOXC 2在CRC进展中起重要作用，并可能作为该疾病的有价值的临床预后标志物。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and ART pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.