Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer.
Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer.
复制标题
类风湿滑膜中细胞粘附受体整合素家族的表达。
作者：
L. Nikkari;H. Aho;T. Yli;H. Larjava;M. Jalkanen;J. Heino
整合素是异源二聚体细胞粘附受体。β 1整联蛋白亚基可以与多个α亚基形成复合物，并形成胶原蛋白、层粘连蛋白、纤连蛋白和玻连蛋白的受体。我们的特点是八个整合素亚基在类风湿性滑膜中的分布，特别是衬里细胞层。β 1整合素亚基在滑膜基质和衬里细胞中大量存在。在衬里细胞中唯一经常看到的α亚基是α 6。与α β亚基复合，α 6形成层粘连蛋白受体，通常见于上皮细胞或内皮细胞或巨噬细胞。层粘连蛋白存在于滑膜细胞周围的细胞外基质中，这一事实表明α 6整合素在滑膜衬里细胞粘附中的重要性。此外，α 6表达在强烈增殖的衬里细胞层中明显较弱，表明炎症过程可能调节整合素表达。细胞粘附受体的表达改变和类风湿衬里细胞的病理行为之间的潜在联系的建议。
Integrins are heterodimeric cell adhesion receptors. The beta 1 integrin subunit can be in a complex with multiple a subunits and form receptors for collagen, laminin, fibronectin, and vitronectin. We have characterized the distribution of eight integrin subunits in rheumatoid synovium, with special interest in the lining cell layer. The beta 1 integrin subunit was found in abundance in synovial stroma and in lining cells. The only alpha subunit seen constantly in lining cells was alpha 6. In complex with alpha beta subunit, alpha 6 forms a laminin receptor usually seen in epithelial or endothelial cells or in macrophages. The fact that laminin was found in the extracellular matrix around synovial cells suggests the importance of alpha 6 integrin in the adhesion of synovial lining cells. Furthermore, alpha 6 expression was noticeably weaker in strongly proliferative lining cell layers, indicating that the inflammatory process may regulate integrin expression. A potential connection between altered expression of cell adhesion receptors and the pathological behavior of rheumatoid lining cells is suggested.