Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder
Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder
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DOI：
10.1007/s11682-016-9585-7
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发表时间：
2016-08
影响因子：
3.2
通讯作者：
C. Xie;Lisha Ma;Nan Jiang;Ruyan Huang;Li Li-Li;L. Gong;Cancan He;Chao-yong Xiao;Wen Liu;Shu Xu;Zhijun Zhang
中科院分区：
文献类型：
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作者：
C. Xie;Lisha Ma;Nan Jiang;Ruyan Huang;Li Li-Li;L. Gong;Cancan He;Chao-yong Xiao;Wen Liu;Shu Xu;Zhijun Zhang
强迫症（OCD）患者经常观察到奖赏处理过程的改变和认知缺陷；然而，奖励回路和认知控制（CC）系统之间的活动不平衡是否与强迫行为有关仍然未知。 68 名强迫症患者和 33 名认知正常 (CN) 健康受试者参加了这项静息态功能磁共振成像研究。定量评估并比较各组之间奖励回路和 CC 系统之间功能连接的变化。格兰杰因果关系分析用于确定所有受试者的奖励回路和 CC 系统之间和内部的因果信息影响。与 CN 受试者相比，强迫症患者表现出奖赏回路功能耦合增强和 CC 系统功能耦合减弱的二分模式。强迫行为的神经相关性主要位于强迫症患者的奖赏回路和 CC 系统中。重要的是，相对于 CN 受试者，CC 系统对 OCD 患者奖励系统的区域间因果影响较小。这项研究的局限性在于它是一项横断面研究，没有探讨环境和遗传因素的潜在影响。强迫症患者在休息时表现出奖赏回路和 CC 系统之间的功能联系不平衡。这种对失去控制的偏见可能会定义一种病理状态，在这种状态下，受试者更容易做出强迫行为。
Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD patients and 33 cognitively normal (CN) healthy subjects participated in this resting-state functional magnetic resonance imaging study. Alterations in the functional connectivity between reward circuits and the CC system were quantitatively assessed and compared between the groups. A Granger causality analysis was used to determine the causal informational influence between and within reward circuits and the CC system across all subjects. OCD patients showed a dichotomous pattern of enhanced functional coupling in their reward circuits and a weakened functional coupling in their CC system when compared to CN subjects. Neural correlates of compulsive behavior were primarily located in the reward circuits and CC system in OCD patients. Importantly, the CC system exerted a reduced interregional causal influence over the reward system in OCD patients relative to its effect in CN subjects. The limitations of this study are that it was a cross-sectional study and the potential effects of environmental and genetic factors were not explored. OCD patients showed an imbalance in the functional link between reward circuits and the CC system at rest. This bias toward a loss of control may define a pathological state in which subjects are more vulnerable to engaging in compulsive behaviors.