Effects of aerobic physical exercise on inflammation and atherosclerosis in men:: The DNASCO study -: A six-year randomized controlled trial
Effects of aerobic physical exercise on inflammation and atherosclerosis in men:: The DNASCO study -: A six-year randomized controlled trial
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DOI：
10.7326/0003-4819-140-12-200406150-00010
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发表时间：
2004-06-15
影响因子：
39.2
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Rauramaa, R;Halonen, P;Bouchard, C
背景资料：尽管经常性的体育锻炼被推荐用于预防心血管疾病，但在一般人群中没有关于其抗动脉粥样硬化作用的数据。目的：确定渐进式有氧运动与日常活动相比是否能减缓男性动脉粥样硬化的进展。设计：一项为期6年的随机对照试验。设置：芬兰东部。参与者：140名中年男性从人口登记处随机选择。干预：低至中等强度的有氧运动。测量：动脉粥样硬化是定量超声作为平均内膜中层厚度在颈动脉在基线和在第2年至第6年。根据意向治疗分析，6年后运动组的解释性有氧阈值明显净增加19.5%（P < 0.001）。运动组高敏C反应蛋白水平低于对照组，但无统计学意义（P > 0.2）。颈动脉内膜中层厚度的进展在研究组之间没有差异（P > 0.2）。一项排除服用他汀类药物男性的亚组分析显示，经吸烟和每年测量的低密度脂蛋白胆固醇水平、收缩压和腰围调整后，运动组的6年内膜中层厚度进展要少40（0.12 mm [95% CI，-0.010至0.26 mm]）比对照组（0.20 mm [CI，0.05至0.35 mm]）。局限性：仅纳入中年白色男性。干预措施主要包括有氧运动。结论：有氧体育锻炼并没有减弱动脉粥样硬化的进展，除了在一个亚组的男性不服用他汀类药物。
Background: Although regular physical activity is recommended for prevention of cardiovascular diseases, no data are available on its antiatherosclerotic effects in the general population.Objective: To determine whether progressive aerobic exercise compared with usual activity slows progression of atherosclerosis in men.Design: A 6-year randomized, controlled trial.Setting: Eastern Finland.Participants: 140 middle-aged men randomly selected from the population registry.Intervention: Low- to moderate-intensity aerobic exercise.Measurements: Atherosclerosis was quantitated ultrasonographically as the mean intima-media thickness in the carotid artery at baseline and at years 2 through 6.Results: On the basis of intention-to-treat analyses, a 19.5% net increase (P < 0.001) in ventilatory aerobic threshold was evident in the exercise group after 6 years. High-sensitivity C-reactive protein levels were statistically nonsignificantly lower in the exercise group than in the control group (P > 0.2). The progression of intima-media thickness in the carotid artery did not differ between the study groups (P > 0.2). A subgroup analysis that excluded men taking statins showed that the 6-year progression of intima-media thickness, adjusted for smoking and annual measures of low-density lipoprotein cholesterol level, systolic blood pressure, and waist circumference, was 40% less in the exercise group (0.12 mm [95% CI, -0.010 to 0.26 mm]) than in the control group (0.20 mm [CI, 0.05 to 0.35 mm]).Limitations: only middle-aged white men were included. The intervention included mainly aerobic exercises.Conclusions: Aerobic physical exercise did not attenuate progression of atherosclerosis, except in a subgroup of men not taking statins.