CtBP represses Dpp signaling as a dimer
CtBP represses Dpp signaling as a dimer
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CtBP 作为二聚体抑制 Dpp 信号传导
DOI：
10.1016/j.bbrc.2017.12.018
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发表时间：
2018-01-08
影响因子：
3.1
通讯作者：
Xie, Hao
中科院分区：
文献类型：
--
作者：
Bi, Caili;Meng, Fei;Xie, Hao
C-terminal binding protein（CtBP）是一种在动物发育和人类疾病中高度保守的转录辅抑制因子。在果蝇中，CtBP对果蝇的发育至关重要，并且被认为在包括Dpp/BMP通路在内的许多信号通路中发挥其抑制作用。在这里，我们提供的证据表明，虽然野生型CtBP负面和占主导地位的影响Dpp信号在飞推定翅膀，突变体CtBP不能形成二聚体不，表明二聚体是必需的CtBP在体内Dpp信号的抑制作用。(C)2017爱思唯尔公司All rights reserved.
C-terminal binding protein (CtBP) is a highly conserved transcriptional co-repressor in animal development and human diseases. In Drosophila, CtBP is critical for fly development and is thought to exert its repressive roles in many signaling pathways including Dpp/BMP pathway. Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo. (C) 2017 Elsevier Inc. All rights reserved.