Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects.
Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects.
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DOI：
10.1002/oby.20803
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发表时间：
2014-09
期刊：
影响因子：
6.9
通讯作者：
Klein, Samuel
中科院分区：
文献类型：
--
作者：
Bradley, David;Magkos, Faidon;Eagon, J. Christopher;Varela, J. Esteban;Gastaldelli, Amalia;Okunade, Adewole L.;Patterson, Bruce W.;Klein, Samuel
我们评估了Roux-en-Y胃旁路术（RYGB）或袖状胃切除术（SG）手术诱导的显著体重减轻对胰岛素敏感性、β细胞功能和对混合餐的代谢反应的影响。14名计划接受SG（n=7）或RYGB（n=7）手术的非糖尿病胰岛素抵抗患者在手术前和体重减轻约20%后完成了高胰岛素-正葡萄糖钳夹术和混合餐耐量试验。胰岛素敏感性（钳夹过程中胰岛素刺激的葡萄糖处置）、口服葡萄糖耐量（餐后血糖曲线下面积）和β细胞功能（与胰岛素敏感性相关的胰岛素分泌）在体重减轻后改善，手术组之间无差异。RYGB或SG后对膳食摄入的代谢反应相似，表现为摄入的葡萄糖快速输送到体循环中，两组中的血糖、胰岛素和C肽浓度在餐后早期大幅增加。我们的结论是，当体重减轻相匹配时，RYGB和SG手术在调节血糖稳态的两个主要因素中导致相似的改善，胰岛素敏感性和β细胞功能在肥胖的非糖尿病患者中。
We evaluated the effects of marked weight loss, induced by Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, β-cell function and the metabolic response to a mixed meal. Fourteen non-diabetic insulin-resistant patients who were scheduled to undergo SG (n=7) or RYGB (n=7) procedures completed a hyperinsulinemic-euglycemic clamp procedure and a mixed-meal tolerance test before surgery and after losing ∼20% of their initial body weight. Insulin sensitivity (insulin-stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and β-cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin and C-peptide concentrations in both groups. We conclude that, when matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and β-cell function in obese people without diabetes.
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影响因子：
16.2
作者：
Kashyap SR;Bhatt DL;Wolski K;Watanabe RM;Abdul-Ghani M;Abood B;Pothier CE;Brethauer S;Nissen S;Gupta M;Kirwan JP;Schauer PR
通讯作者：
Schauer PR
影响因子：
7.7
作者：
Bergman, RN;Ader, M;Van Citters, G
通讯作者：
Van Citters, G
影响因子：
6.7
作者：
Gastaldelli, A.;Casolaro, A.;Ferrannini, E.
通讯作者：
Ferrannini, E.
影响因子：
2.9
作者：
Peterli, Ralph;Steinert, Robert E.;Woelnerhanssen, Bettina;Peters, Thomas;Christoffel-Courtin, Caroline;Gass, Markus;Kern, Beatrice;von Fluee, Markus;Beglinger, Christoph
通讯作者：
Beglinger, Christoph
DOI：
10.1073/pnas.0904944106
发表时间：
2009-09-08
影响因子：
11.1
作者：
Fabbrini, Elisa;Magkos, Faidon;Klein, Samuel
通讯作者：
Klein, Samuel