Age-related cellular and microstructural changes in the rotator cuff enthesis.
Age-related cellular and microstructural changes in the rotator cuff enthesis.
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DOI：
10.1002/jor.25211
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发表时间：
2022-08
影响因子：
2.8
通讯作者：
Gingery, Anne
中科院分区：
文献类型：
--
作者：
Long, Zeling;Nakagawa, Koichi;Wang, Zhanwen;Amadio, Peter C.;Zhao, Chunfeng;Gingery, Anne
肩袖损伤随年龄增长而增加。髋端是肩袖损伤和退变最常见的部位。了解与年龄相关的椎体变化对于确定肩袖损伤、退变的机制以及指导机械驱动的治疗至关重要。在这项研究中，我们探讨了年轻、成熟和老年大鼠肩袖内套的年龄相关细胞变化。研究结果表明，古岩体具有矿化带增多、非矿化带减少的特征。随着年龄的增长，肩袖来源细胞（RCECs）的增殖、迁移和集落形成潜力减弱。老年RCECs的成肌腱和成软骨潜能显著降低，而成骨潜能增加。随着年龄的增长，RCECs的成脂潜能增加。本研究探讨了年轻、成熟和年老的肩袖内囊细胞之间的细胞差异，强调了使用适合年龄的模型的重要性，并为进一步描述肩袖损伤的机制和潜在治疗方法提供了基础。
Rotator cuff injuries increase with age. The enthesis is the most frequent site of rotator cuff injury and degeneration. Understanding age-related changes of the enthesis are essential to determine the mechanism of rotator cuff injuries, degeneration, and to guide mechanistically driven therapies. In this study, we explored age-related cellular changes of the rotator cuff enthesis in young, mature, and aged rats. Here we found that the aged enthesis is typified by an increased mineralized zone and decreased non-mineralized zone. Proliferation, migration, and colony forming potential of rotator cuff derived cells (RCECs) was attenuated with aging. The tenogenic and chondrogenic potential were significantly reduced, while the osteogenic potential increased in aged RCECs. The adipogenic potential increased in RCECs with age. This study explores the cellular differences found between young, mature, and aged rotator cuff enthesis cells and highlights the importance of using age appropriate models, as well as provides a basis for further delineation of mechanisms and potential therapeutics for rotator cuff injuries.
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
20.3
作者：
Deregibus, Maria Chiara;Cantaluppi, Vincenzo;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
2.4
作者：
Benjamin, M;Toumi, H;Milz, S
通讯作者：
Milz, S
高表达肌腱调节蛋白的间充质干细胞是肌腱损伤愈合的更好细胞来源。
影响因子：
--
作者：
Hou Y;Ni M;Lin S;Sun Y;Lin W;Liu Y;Wang H;He W;Li G;Xu L
通讯作者：
Xu L
影响因子：
2.3
作者：
Longo UG;Risi Ambrogioni L;Candela V;Berton A;Carnevale A;Schena E;Denaro V
通讯作者：
Denaro V