Elevated rates of ADHD in mothers of children with comorbid ADHD and epilepsy.
Elevated rates of ADHD in mothers of children with comorbid ADHD and epilepsy.
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DOI：
10.2217/npy.12.53
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发表时间：
2012-10-01
期刊：
影响因子：
--
通讯作者：
Biederman J
中科院分区：
文献类型：
--
作者：
Gonzalez-Heydrich J;Hamoda HM;Luna L;Rao S;McClendon J;Rotella P;Waber D;Boyer K;Faraone SV;Whitney J;Guild D;Biederman J
描述ADHD和癫痫共病（ADHD+E）患儿母亲的ADHD患病率，并比较有（Fam+）和无（Fam−）额外亲属患有癫痫的母亲的ADHD症状。采用《学龄期儿童情感障碍和精神分裂症儿童时间表》ADHD模块和ADHD评定量表IV对患有ADHD+E儿童的母亲（n = 16）进行评估。收集样本中患有癫痫的一级或二级亲属存在（Fam+）或不存在（Fam -）的信息。总共有50%的母亲符合DSM-IV的ADHD标准。与Fam -母亲（36%,p = 0.14）相比，Fam+母亲（80%）中ADHD更为普遍。Fam+母亲比Fam−母亲有更多的当前多动症症状（p = 0.002），更高的当前多动症严重程度（p = 0.02）和更高的ADHD评定量表IV多动症评分（p = 0.008）。在这项初步研究中，ADHD+E患儿母亲的ADHD患病率升高，表明癫痫患儿及其母亲的ADHD症状反映了共同的家族遗传或环境风险，可能导致家庭成员中这两种疾病的患病率更高。这是一项初步研究，需要进行更大规模的对照研究。
To describe the prevalence of ADHD in mothers of children with comorbid ADHD and epilepsy (ADHD+E) and to compare ADHD symptoms in mothers with (Fam+) and without (Fam−) additional relative(s) with epilepsy. Mothers (n = 16) of children with ADHD+E were assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children ADHD module and the ADHD Rating Scale IV. Information was collected on the presence (Fam+) or absence (Fam−) of first- or second-degree relatives with epilepsy in the sample. A total of 50% of mothers met the DSM-IV criteria for ADHD. ADHD was more prevalent in Fam+ mothers (80%) compared with Fam− mothers (36%; p = 0.14). Fam+ mothers had more current hyperactivity symptoms than Fam− mothers (p = 0.002), higher current ADHD severity (p = 0.02) and higher ADHD Rating Scale IV hyperactivity scores (p = 0.008). The prevalence of ADHD in mothers of children with ADHD+E is elevated in this pilot study, suggesting that ADHD symptoms in children with epilepsy and their mothers reflects shared familial genetic or environmental risks, potentially resulting in a higher prevalence of both disorders among family members. This is a pilot study and larger controlled studies are warranted.
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影响因子：
5.3
作者：
Reimherr, Frederick W.;Williams, Erika D.;Marchant, Barrie K.
通讯作者：
Marchant, Barrie K.
影响因子：
3.8
作者：
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影响因子：
2.6
作者：
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影响因子：
1.6
作者：
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通讯作者：
Griebel, ML
影响因子：
2.6
作者：
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通讯作者：
Yalcinkaya, C