Lymphoepithelioma-like carcinoma of breast-evaluation for Epstein-Barr virus-encoded RNA, human papillomavirus, and markers of basal cell differentiation
Lymphoepithelioma-like carcinoma of breast-evaluation for Epstein-Barr virus-encoded RNA, human papillomavirus, and markers of basal cell differentiation
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DOI：
10.1016/j.anndiagpath.2016.05.006
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发表时间：
2016-12-01
影响因子：
2
通讯作者：
Desai, Sangeeta
中科院分区：
文献类型：
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作者：
Shet, Tanuja;Pai, Trupti;Desai, Sangeeta
这是5例乳腺淋巴上皮瘤样癌(LEC)中最大的一组，试图观察基底细胞角蛋白(CKS)、人乳头瘤病毒和EB病毒编码的RNA在这些肿瘤中的表达。在对所有淋巴组织密集浸润性乳腺癌进行严格评估后，选择了5例。组织学上，除1例肉芽肿性反应异常外，其余均为典型的组织学改变。所有肿瘤的雌孕激素受体和HER2(三阴性)均为阴性。3例肿瘤表达CK5/6和高分子量CK，仅1例有淋巴结转移的肿瘤表达CK14。石蜡组织中EB病毒编码的RNA和人乳头状瘤病毒DNA的原位杂交分析在所有肿瘤中均为阴性。所有患者均接受了辅助治疗。1例肿瘤表达基本标志物CK5/6的患者在治疗完成53个月后发生对侧乳腺恶性肿瘤。其余患者无疾病，随访6~105个月。乳腺淋巴上皮瘤样癌表达基础CK谱，CK5/6阳性率高于CK14。分析这些肿瘤中的基本标记物可能有助于完善这些肿瘤的定义，并将它们归类为预后相关的组。(C)2016 Elsevier Inc.保留所有权利。
This is a largest series of 5 cases of lymphoepithelioma-like carcinoma (LEC) of the breast attempting to look at the expression of basal cytokeratins (CKs), human papillomavirus, and Epstein-Barr virus-encoded RNAs in these tumors. Five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. Histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. All tumors were negative for estrogen and progesterone receptors and HER2 (triple negative). Three tumors expressed CK5/6 and high-molecular-weight CK, whereas only the case with nodal metastasis expressed CK14. Analysis for in situ hybridization for Epstein-Barr virus-encoded RNAs and human papillomavirus DNA on paraffin-processed tissues was negative in all tumors. All of these patients received adjuvant therapy. One patient with tumor expressing basal marker, CK5/6, had contralateral breast malignancy after a duration of 53 months of treatment completion. The rest were disease free with the follow-up period in the range of 6 to 105 months. The lymphoepithelioma-like carcinoma of breast expressed basal CK profile that is more CK5/6 positive than CK14. Analysis of basal markers within these tumors may help in refining the definition of these tumors and in classifying them into prognostically relevant groups. (C) 2016 Elsevier Inc. All rights reserved.