Expression of HGF and cMet in the developing and adult brain
Expression of HGF and cMet in the developing and adult brain
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DOI：
10.1016/s0165-3806(97)00108-9
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发表时间：
1997-09-20
期刊：
影响因子：
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通讯作者：
Michalopoulos, GK
中科院分区：
文献类型：
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作者：
Achim, CL;Katyal, S;Michalopoulos, GK
肝细胞生长因子（HGF）最近被认为是大脑发育中潜在的神经营养因子。我们使用 Northern 印迹分析和 mRNA 原位杂交以及双免疫荧光激光共聚焦显微镜研究了 HGF 及其受体的表达。 HGF 和 cMet 信息在人类和大鼠大脑的海马体中都很丰富。在这个区域，这两种信息都集中在神经元层。 HGF 主要在海马 CA3-4 中分离，cMet 在 CA1 中主要分离，这支持了 HGF 可能介导发育中和成人大脑中重要神经营养功能的假设。 (C) 1997 Elsevier Science B.V.
Hepatocyte growth factor (HGF) was recently recognized as a potential neurotrophic factor in the developing brain. We studied expression of HGF and its receptor using Northern blot analysis and in situ hybridization for mRNA and double immunofluorescent laser confocal microscopy. HGF and cMet messages were abundant in the hippocampus of both human and rat brains. in this region, both messages were localized in the neuronal layer. Segregation of HGF predominantly in the hippocampal CA3-4 and cMet in CA1 supports the hypothesis that HGF may mediate important neurotrophic functions in both developing and adult brains. (C) 1997 Elsevier Science B.V.