CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer.
CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer.
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DOI：
10.1155/2020/9435030
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发表时间：
2020
影响因子：
4.1
通讯作者：
Arrieta O
中科院分区：
文献类型：
--
作者：
Catalán R;Orozco-Morales M;Hernández-Pedro NY;Guijosa A;Colín-González AL;Ávila-Moreno F;Arrieta O
CD 47是免疫球蛋白超家族中的细胞表面蛋白，其通常在每个健康细胞中以低水平表达。它的主要生理功能是作为吞噬作用的抑制剂;这发生在与巨噬细胞上表达的SIRPa相互作用的整个过程中。CD 47和SIRPa之间的相互作用导致酪氨酸磷酸酶的活化，酪氨酸磷酸酶抑制肌球蛋白在吞噬突触的亚膜组装位点的积累，导致吞噬作用阻断。通过这种方式，CD 47对健康的自身细胞起到了“不要吃我”的信号作用;因此，CD 47的丢失会导致衰老或受损细胞的吞噬作用。利用CD 47提供的这种抗吞噬信号，许多类型的肿瘤过度表达这种蛋白质，从而避免巨噬细胞的吞噬作用并帮助癌细胞存活。本文综述了CD 47的生理和病理生理作用;总结了CD 47作为肿瘤潜在生物标志物和/或治疗靶点的高质量信息;最后，我们对CD 47与非小细胞肺癌、EGFR突变和肿瘤微环境的相关信息进行了深入分析。
CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs throughout interaction with SIRPa expressed on macrophages. Interaction between CD47 and SIRPa leads to activation of tyrosine phosphatases that inhibit myosin accumulation at the submembrane assembly site of the phagocytic synapse, resulting in phagocytosis blockade. In this way CD47 acts as a “don´t eat me signal” for healthy self-cells; accordingly, loss of CD47 leads to phagocytosis of aged or damaged cells. Taking advantage of this anti-phagocytic signal provided by CD47, many types of tumors overexpress this protein, thereby avoiding phagocytosis by macrophages and aiding in the survival of cancer cells. The aim of this review is to describe the physiologic the pathophysiologic role of CD47; summarize the available high-quality information about this molecule as a potential biomarker and/or therapeutic target in cancer; finally, we present an in-depth analysis of the available information about CD47 in association with nonsmall cell lung cancer, EGFR mutations, and tumor microenvironment.
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CD47是人类急性髓样白血病干细胞的不良预后因素和治疗抗体靶标。
影响因子：
64.5
作者：
Majeti R;Chao MP;Alizadeh AA;Pang WW;Jaiswal S;Gibbs KD Jr;van Rooijen N;Weissman IL
通讯作者：
Weissman IL
影响因子：
--
作者：
Baccelli I;Stenzinger A;Vogel V;Pfitzner BM;Klein C;Wallwiener M;Scharpff M;Saini M;Holland-Letz T;Sinn HP;Schneeweiss A;Denkert C;Weichert W;Trumpp A
通讯作者：
Trumpp A
DOI：
10.1158/1078-0432.ccr-17-2283
发表时间：
2018-03-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Michaels AD;Newhook TE;Adair SJ;Morioka S;Goudreau BJ;Nagdas S;Mullen MG;Persily JB;Bullock TNJ;Slingluff CL Jr;Ravichandran KS;Parsons JT;Bauer TW
通讯作者：
Bauer TW
影响因子：
11.2
作者：
Manna, PP;Frazier, WA
通讯作者：
Frazier, WA
影响因子：
16.6
作者：
Feng, Mingye;Marjon, Kristopher D.;Weissman, Irving L.
通讯作者：
Weissman, Irving L.