Acute lower leg hot water immersion protects macrovascular dilator function following ischaemia-reperfusion injury in humans.
Acute lower leg hot water immersion protects macrovascular dilator function following ischaemia-reperfusion injury in humans.
复制标题
急性小腿热水浸泡可保护人类缺血再灌注损伤后的大血管扩张功能。
DOI：
10.1113/ep088154
复制
发表时间：
2020
影响因子：
2.7
通讯作者：
Romero,StevenA
中科院分区：
文献类型：
--
作者：
Engelland,RachelE;Hemingway,HoldenW;Tomasco,OliviaG;Olivencia-Yurvati,AlbertH;Romero,StevenA
新发现·本研究的中心问题是什么？小腿热水浸泡对年轻健康人手臂血管缺血再灌注损伤有何影响？·主要发现及其重要性是什么？小腿热水浸泡成功地保护了人类血管缺血再灌注损伤。这就提出了一种可能性，即有针对性的加热小腿可能是一种替代治疗方法，全身加热，是同样有效的保护免受血管缺血-再灌注injuries.AbstractReperfusion，以下一段时间的缺血矛盾降低血管舒张功能在人类和有助于组织损伤与缺血事件。急性全身热水浸泡可保护年轻健康人免受血管缺血再灌注（I-R）损伤。然而，急性小腿发热对I-R损伤的影响尚不清楚。因此，本研究的目的是检验以下假设：与热中性对照浸泡相比，急性小腿热水浸泡可防止年轻健康人I-R损伤后大血管和微血管扩张功能下降。10名年轻的健康受试者（5名女性）在两种随机条件下将其小腿浸入循环水浴中60 min：（1）热中性对照浸泡（33°C）和（2）热水浸泡（42°C）。在三个时间点使用多普勒超声评估大血管（肱动脉血流介导的扩张）和微血管（前臂反应性充血）扩张器功能：（1）浸泡前，（2）浸泡后60分钟，和（3）I/R后（手臂缺血20分钟，然后再灌注20分钟）。对照浸泡后，缺血再灌注损伤降低了大血管扩张器功能（浸泡前6.0 ± 2.1% vs. I/R后3.6 ± 2.1%;P< 0.05），但在先前热水浸泡后保持良好（浸泡前5.8 ± 2.1% vs. I/R后5.3 ± 2.1%;P= 0.8）。不同条件或不同时间的微血管扩张器功能无差异。总之，急性小腿热水浸泡可防止年轻健康人I-R损伤后发生的大血管扩张功能下降。
New Findings•What is the central question of this study?What is the effect of lower leg hot water immersion on vascular ischaemia–reperfusion injury induced in the arm of young healthy humans?•What is the main finding and its importance?Lower leg hot water immersion successfully protects against vascular ischaemia–reperfusion injury in humans. This raises the possibility that targeted heating of the lower legs may be an alternative therapeutic approach to whole‐body heating that is equally efficacious at protecting against vascular ischaemia–reperfusion injury.AbstractReperfusion that follows a period of ischaemia paradoxically reduces vasodilator function in humans and contributes to the tissue damage associated with an ischaemic event. Acute whole‐body hot water immersion protects against vascular ischaemia–reperfusion (I–R) injury in young healthy humans. However, the effect of acute lower leg heating on I–R injury is unclear. Therefore, the purpose of this study was to test the hypothesis that, compared with thermoneutral control immersion, acute lower leg hot water immersion would prevent the decrease in macro‐ and microvascular dilator functions following I–R injury in young healthy humans. Ten young healthy subjects (5 female) immersed their lower legs into a circulated water bath for 60 min under two randomized conditions: (1) thermoneutral control immersion (∼33°C) and (2) hot water immersion (∼42°C). Macrovascular (brachial artery flow‐mediated dilatation) and microvascular (forearm reactive hyperaemia) dilator functions were assessed using Doppler ultrasound at three time points: (1) pre‐immersion, (2) 60 min post‐immersion, and (3) post‐I/R (20 min of arm ischaemia followed by 20 min of reperfusion). Ischaemia–reperfusion injury reduced macrovascular dilator function following control immersion (pre‐immersion 6.0 ± 2.1%vs. post‐I/R 3.6 ± 2.1%;P< 0.05), but was well‐maintained with prior hot water immersion (pre‐immersion 5.8 ± 2.1%vs. post‐I/R 5.3 ± 2.1%;P= 0.8). Microvascular dilator function did not differ between conditions or across time. Taken together, acute lower leg hot water immersion prevents the decrease in macrovascular dilator function that occurs following I–R injury in young healthy humans.